1bhd
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1bhd.gif|left|200px]] | [[Image:1bhd.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1bhd", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | + | or leave the SCENE parameter empty for the default display. | |
| - | + | --> | |
| - | + | {{STRUCTURE_1bhd| PDB=1bhd | SCENE= }} | |
| - | + | ||
| - | | | + | |
| - | }} | + | |
'''SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN''' | '''SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN''' | ||
| Line 28: | Line 25: | ||
[[Category: Kendrick-Jones, J.]] | [[Category: Kendrick-Jones, J.]] | ||
[[Category: Winder, S J.]] | [[Category: Winder, S J.]] | ||
| - | [[Category: | + | [[Category: Actin binding]] |
| - | [[Category: | + | [[Category: Calponin homology]] |
| - | [[Category: | + | [[Category: Structural protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:30:57 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 08:30, 2 May 2008
SECOND CALPONIN HOMOLOGY DOMAIN FROM UTROPHIN
Overview
Utrophin is a close homologue of dystrophin, the protein defective in Duchenne muscular dystrophy. Like dystrophin, it is composed of three regions: an N-terminal region that binds actin filaments, a large central region with triple coiled-coil repeats, and a C-terminal region that interacts with components in the dystroglycan protein complex at the plasma membrane. The N-terminal actin-binding region consists of two calponin homology domains and is related to the actin-binding domains of a superfamily of proteins including alpha-actinin, spectrin and fimbrin. Here, we present the 2.0 A structure of the second calponin homology domain of utrophin solved by X-ray crystallography, and compare it to the other calponin homology domains previously determined from spectrin and fimbrin.
About this Structure
1BHD is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The 2.0 A structure of the second calponin homology domain from the actin-binding region of the dystrophin homologue utrophin., Keep NH, Norwood FL, Moores CA, Winder SJ, Kendrick-Jones J, J Mol Biol. 1999 Jan 22;285(3):1257-64. PMID:9887274 Page seeded by OCA on Fri May 2 11:30:57 2008
