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5fph
From Proteopedia
(Difference between revisions)
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| - | ''' | + | ==The GTPase domains of the immunity-related Irga6 dimerize in a parallel head-to-head fashion== |
| - | + | <StructureSection load='5fph' size='340' side='right' caption='[[5fph]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fph]] is a 7 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |
| - | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fph OCA], [http://pdbe.org/5fph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fph RCSB], [http://www.ebi.ac.uk/pdbsum/5fph PDBsum]</span></td></tr> | |
| - | [[Category: | + | </table> |
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IIGP1_MOUSE IIGP1_MOUSE]] GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction.<ref>PMID:11907101</ref> <ref>PMID:16304607</ref> <ref>PMID:19242543</ref> <ref>PMID:12732635</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Daumke, O]] | ||
[[Category: Faelber, K]] | [[Category: Faelber, K]] | ||
[[Category: Froehlich, C]] | [[Category: Froehlich, C]] | ||
| - | [[Category: Schulte, K]] | ||
[[Category: Howard, J]] | [[Category: Howard, J]] | ||
[[Category: Pawlowski, N]] | [[Category: Pawlowski, N]] | ||
| - | [[Category: | + | [[Category: Schulte, K]] |
| + | [[Category: Dynamin superfamily]] | ||
| + | [[Category: Gmppnp]] | ||
| + | [[Category: Gtpase]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Innate immunity]] | ||
| + | [[Category: Irg protein]] | ||
| + | [[Category: Irga6]] | ||
| + | [[Category: Oligomerization]] | ||
Revision as of 17:28, 10 February 2016
The GTPase domains of the immunity-related Irga6 dimerize in a parallel head-to-head fashion
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Categories: Daumke, O | Faelber, K | Froehlich, C | Howard, J | Pawlowski, N | Schulte, K | Dynamin superfamily | Gmppnp | Gtpase | Hydrolase | Innate immunity | Irg protein | Irga6 | Oligomerization
