5h85

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'''Unreleased structure'''
 
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The entry 5h85 is ON HOLD until Dec 23 2017
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==Crystal structure of the bromodomain of human CREBBP in complex with UO37D==
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<StructureSection load='5h85' size='340' side='right' caption='[[5h85]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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Authors: Dong, J., Caflisch, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5h85]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5H85 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5H85 FirstGlance]. <br>
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Description: Crystal structure of the bromodomain of human CREBBP in complex with UO37D
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5XS:METHYL+3-(7~{H}-PURIN-6-YLCARBAMOYL)BENZOATE'>5XS</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histone_acetyltransferase Histone acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.48 2.3.1.48] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5h85 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5h85 OCA], [http://pdbe.org/5h85 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5h85 RCSB], [http://www.ebi.ac.uk/pdbsum/5h85 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5h85 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Note=Chromosomal aberrations involving CREBBP may be a cause of acute myeloid leukemias. Translocation t(8;16)(p11;p13) with KAT6A; translocation t(11;16)(q23;p13.3) with MLL/HRX; translocation t(10;16)(q22;p13) with KAT6B. KAT6A-CREBBP may induce leukemia by inhibiting RUNX1-mediated transcription. Defects in CREBBP are a cause of Rubinstein-Taybi syndrome type 1 (RSTS1) [MIM:[http://omim.org/entry/180849 180849]]. RSTS1 is an autosomal dominant disorder characterized by craniofacial abnormalities, broad thumbs, broad big toes, mental retardation and a propensity for development of malignancies.<ref>PMID:11331617</ref> <ref>PMID:12114483</ref> <ref>PMID:12566391</ref> <ref>PMID:15706485</ref>
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== Function ==
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[[http://www.uniprot.org/uniprot/CBP_HUMAN CBP_HUMAN]] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300.<ref>PMID:9707565</ref> <ref>PMID:11154691</ref> <ref>PMID:12738767</ref> <ref>PMID:12929931</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Histone acetyltransferase]]
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[[Category: Caflisch, A]]
[[Category: Dong, J]]
[[Category: Dong, J]]
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[[Category: Caflisch, A]]
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[[Category: Inhibitor]]
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[[Category: Transcription]]
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[[Category: Transferase]]

Revision as of 16:26, 18 January 2017

Crystal structure of the bromodomain of human CREBBP in complex with UO37D

5h85, resolution 1.70Å

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