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1bil

From Proteopedia

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[[Image:1bil.jpg|left|200px]]
[[Image:1bil.jpg|left|200px]]
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{{Structure
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|PDB= 1bil |SIZE=350|CAPTION= <scene name='initialview01'>1bil</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1bil", creates the "Structure Box" on the page.
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|LIGAND= <scene name='pdbligand=CHA:1-HYDROXY-2-AMINO-3-CYCLOHEXYLPROPANE'>CHA</scene>, <scene name='pdbligand=DMF:DIMETHYLFORMAMIDE'>DMF</scene>, <scene name='pdbligand=HII:2-METHYL-3-(2-AMINOTHIAZOLO)PROPANAL'>HII</scene>, <scene name='pdbligand=IP3:1-HYDROXY-3-METHYLBUTANE'>IP3</scene>, <scene name='pdbligand=PHC:N-METHYL-N-(METHYLBENZYL)FORMAMIDE'>PHC</scene>
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|GENE= CMV IE-HUMAN PREPRORENIN CDNA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_1bil| PDB=1bil | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bil FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bil OCA], [http://www.ebi.ac.uk/pdbsum/1bil PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bil RCSB]</span>
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'''CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS'''
'''CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Tong, L.]]
[[Category: Tong, L.]]
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[[Category: aspartic proteinase]]
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[[Category: Aspartic proteinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:33:35 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:01:45 2008''
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Revision as of 08:33, 2 May 2008

Image:1bil.jpg

Template:STRUCTURE 1bil

CRYSTALLOGRAPHIC STUDIES ON THE BINDING MODES OF P2-P3 BUTANEDIAMIDE RENIN INHIBITORS


Overview

The binding modes of three peptidomimetic P2-P3 butanediamide renin inhibitors have been determined by x-ray crystallography. The inhibitors are bound with their backbones in an extended conformation, and their side chains occupying the S5 to S1' pockets. A (2-amino-4-thiazolyl)methyl side chain at the P2 position shows stronger hydrogen-bonding and van der Waals interactions with renin than the His side chain, which is present in the natural substrate. The ACHPA-gamma-lactam transition state analog has similar interactions with renin as the dihydroxyethylene transition state analog.

About this Structure

1BIL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystallographic studies on the binding modes of P2-P3 butanediamide renin inhibitors., Tong L, Pav S, Lamarre D, Simoneau B, Lavallee P, Jung G, J Biol Chem. 1995 Dec 8;270(49):29520-4. PMID:7493993 Page seeded by OCA on Fri May 2 11:33:35 2008

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