1bkd

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[[Image:1bkd.gif|left|200px]]
[[Image:1bkd.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_1bkd", creates the "Structure Box" on the page.
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{{STRUCTURE_1bkd| PDB=1bkd | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bkd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bkd OCA], [http://www.ebi.ac.uk/pdbsum/1bkd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bkd RCSB]</span>
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'''COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1'''
'''COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1'''
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[[Category: Margarit, S M.]]
[[Category: Margarit, S M.]]
[[Category: Sagi, D B.]]
[[Category: Sagi, D B.]]
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[[Category: complex (oncogene protein/exchange factor)]]
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[[Category: Exchange factor]]
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[[Category: exchange factor]]
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[[Category: Small gtpase]]
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[[Category: small gtpase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:37:47 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:02:50 2008''
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Revision as of 08:37, 2 May 2008

Image:1bkd.gif

Template:STRUCTURE 1bkd

COMPLEX OF HUMAN H-RAS WITH HUMAN SOS-1


Overview

The crystal structure of human H-Ras complexed with the Ras guanine-nucleotide-exchange-factor region of the Son of sevenless (Sos) protein has been determined at 2.8 A resolution. The normally tight interaction of nucleotides with Ras is disrupted by Sos in two ways. First, the insertion into Ras of an alpha-helix from Sos results in the displacement of the Switch 1 region of Ras, opening up the nucleotide-binding site. Second, side chains presented by this helix and by a distorted conformation of the Switch 2 region of Ras alter the chemical environment of the binding site for the phosphate groups of the nucleotide and the associated magnesium ion, so that their binding is no longer favoured. Sos does not impede the binding sites for the base and the ribose of GTP or GDP, so the Ras-Sos complex adopts a structure that allows nucleotide release and rebinding.

About this Structure

1BKD is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis of the activation of Ras by Sos., Boriack-Sjodin PA, Margarit SM, Bar-Sagi D, Kuriyan J, Nature. 1998 Jul 23;394(6691):337-43. PMID:9690470 Page seeded by OCA on Fri May 2 11:37:47 2008

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