1bml

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[[Image:1bml.gif|left|200px]]
[[Image:1bml.gif|left|200px]]
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{{Structure
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|PDB= 1bml |SIZE=350|CAPTION= <scene name='initialview01'>1bml</scene>, resolution 2.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1bml", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Plasmin Plasmin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.7 3.4.21.7] </span>
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{{STRUCTURE_1bml| PDB=1bml | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bml FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bml OCA], [http://www.ebi.ac.uk/pdbsum/1bml PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bml RCSB]</span>
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}}
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'''COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PLASMIN AND STREPTOKINASE'''
'''COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PLASMIN AND STREPTOKINASE'''
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[[Category: Wang, X.]]
[[Category: Wang, X.]]
[[Category: Zhang, X C.]]
[[Category: Zhang, X C.]]
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[[Category: human plasmin]]
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[[Category: Human plasmin]]
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[[Category: streptokinase]]
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[[Category: Streptokinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:42:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:03:56 2008''
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Revision as of 08:42, 2 May 2008

Image:1bml.gif

Template:STRUCTURE 1bml

COMPLEX OF THE CATALYTIC DOMAIN OF HUMAN PLASMIN AND STREPTOKINASE


Overview

Streptokinase is a plasminogen activator widely used in treating blood-clotting disorders. Complexes of streptokinase with human plasminogen can hydrolytically activate other plasminogen molecules to plasmin, which then dissolves blood clots. A similar binding activation mechanism also occurs in some key steps of blood coagulation. The crystal structure of streptokinase complexed with the catalytic unit of human plasmin was solved at 2.9 angstroms. The amino-terminal domain of streptokinase in the complex is hypothesized to enhance the substrate recognition. The carboxyl-terminal domain of streptokinase, which binds near the activation loop of plasminogen, is likely responsible for the contact activation of plasminogen in the complex.

About this Structure

1BML is a Protein complex structure of sequences from Homo sapiens and Streptococcus dysgalactiae subsp. equisimilis. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic domain of human plasmin complexed with streptokinase., Wang X, Lin X, Loy JA, Tang J, Zhang XC, Science. 1998 Sep 11;281(5383):1662-5. PMID:9733510 Page seeded by OCA on Fri May 2 11:42:09 2008

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