Catabolite gene activator protein

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<StructureSection load='1o3r' size='350' side='right' scene='54/543372/Cv/3' caption='Catabolite gene activator protein complex with cAMP (stick model) and DNA [[1o3r]]'>
<StructureSection load='1o3r' size='350' side='right' scene='54/543372/Cv/3' caption='Catabolite gene activator protein complex with cAMP (stick model) and DNA [[1o3r]]'>
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'''Catabolite gene activator protein''' (CAP) is a DNA-binding protein involved in the transcription of several genes including those involved in the metabolism of sugar. CAP can activate or repress transcription initiation upon binding of cAMP. The cAMP-CAP complex binds to promoters on the DNA. The structure contains a ligand-binding domain (LBD) at the N-terminal and DNA-binding domain (DBD) at the C-terminal. <scene name='54/543372/Cv/4'>Four cAMP molecules bind to the dimeric CAP</scene>. When the amount of glucose transported into the cell is low, cAMP level rises and the cAMP-CAP complex causes increase of transcription of glucose metabolism genes.<ref>PMID:10550204</ref>
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'''Catabolite gene activator protein''' (CAP) is a DNA-binding protein involved in the transcription of several genes including those involved in the metabolism of sugar. CAP can activate or repress transcription initiation upon binding of cAMP. The cAMP-CAP complex binds to promoters on the DNA. The structure contains a ligand-binding domain (LBD) at the N-terminal and DNA-binding domain (DBD) at the C-terminal. <scene name='54/543372/Cv/4'>Four cAMP molecules bind to the dimeric CAP</scene>. When the amount of glucose transported into the cell is low, cAMP level rises and the cAMP-CAP complex causes increase of transcription of glucose metabolism genes. <scene name='54/543372/Cv/6'>1st cAMP binding site</scene><ref>PMID:10550204</ref>
</StructureSection>
</StructureSection>

Revision as of 09:56, 17 January 2016

Catabolite gene activator protein complex with cAMP (stick model) and DNA 1o3r

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3D Structures of catabolite gene activator protein

Updated on 17-January-2016

References

  1. ↑ Busby S, Ebright RH. Transcription activation by catabolite activator protein (CAP). J Mol Biol. 1999 Oct 22;293(2):199-213. PMID:10550204 doi:http://dx.doi.org/10.1006/jmbi.1999.3161

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Alexander Berchansky, Michal Harel, Jaime Prilusky

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