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1bnl

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[[Image:1bnl.gif|left|200px]]
[[Image:1bnl.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1bnl |SIZE=350|CAPTION= <scene name='initialview01'>1bnl</scene>, resolution 2.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1bnl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= COLLAGEN XVIII ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1bnl| PDB=1bnl | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bnl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bnl OCA], [http://www.ebi.ac.uk/pdbsum/1bnl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bnl RCSB]</span>
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}}
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'''ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN'''
'''ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN'''
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[[Category: Timpl, R.]]
[[Category: Timpl, R.]]
[[Category: Wiley, D C.]]
[[Category: Wiley, D C.]]
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[[Category: angiogenic]]
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[[Category: Angiogenic]]
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[[Category: angiogenisis]]
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[[Category: Angiogenisis]]
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[[Category: antiangiogenic]]
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[[Category: Antiangiogenic]]
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[[Category: cancer]]
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[[Category: Cancer]]
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[[Category: collagen]]
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[[Category: Collagen]]
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[[Category: collagen xviii]]
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[[Category: Collagen xviii]]
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[[Category: endostatin]]
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[[Category: Endostatin]]
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[[Category: extracellular matrix]]
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[[Category: Extracellular matrix]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:44:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:04:35 2008''
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Revision as of 08:44, 2 May 2008

Image:1bnl.gif

Template:STRUCTURE 1bnl

ZINC DEPENDENT DIMERS OBSERVED IN CRYSTALS OF HUMAN ENDOSTATIN


Overview

The crystal structure of human endostatin reveals a zinc-binding site. Atomic absorption spectroscopy indicates that zinc is a constituent of both human and murine endostatin in solution. The human endostatin zinc site is formed by three histidines at the N terminus, residues 1, 3, and, 11, and an aspartic acid at residue 76. The N-terminal loop ordered around the zinc makes a dimeric contact in human endostatin crystals. The location of the zinc site at the amino terminus, immediately adjacent to the precursor cleavage site, suggests the possibility that the zinc may be involved in activation of the antiangiogenic activity following cleavage from the inactive collagen XVIII precursor or in the cleavage process itself.

About this Structure

1BNL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Zinc-dependent dimers observed in crystals of human endostatin., Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC, Proc Natl Acad Sci U S A. 1998 Sep 1;95(18):10443-8. PMID:9724722 Page seeded by OCA on Fri May 2 11:44:14 2008

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