1bo0

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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bo0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bo0 OCA], [http://www.ebi.ac.uk/pdbsum/1bo0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bo0 RCSB]</span>
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'''MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE'''
'''MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE'''
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[[Category: Lee, D.]]
[[Category: Lee, D.]]
[[Category: Sykes, B D.]]
[[Category: Sykes, B D.]]
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[[Category: chemotactic cytokine]]
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[[Category: Chemotactic cytokine]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:45:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:04:47 2008''
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Revision as of 08:45, 2 May 2008

Image:1bo0.jpg

Template:STRUCTURE 1bo0

MONOCYTE CHEMOATTRACTANT PROTEIN-3, NMR, MINIMIZED AVERAGE STRUCTURE


Overview

1H-NMR spectroscopy and analytical ultracentrifugation studies reveal that monocyte chemoattractant protein-3 (MCP-3) is a monomer. NMR solution structure shows that MCP-3 adopts an alphabeta fold similar to what is observed in structures of other known chemokines. However, MCP-3 is unique in that it does not show a propensity to form dimers. The closely related chemokines MCP-1 and MCP-2 show a monomer-dimer equilibrium in sedimentation equilibrium studies (approximately 0.2-2 mg/ml). As these proteins are present at nanomolar concentrations in vivo, the results suggest that they are monomeric at functional concentrations and that the monomer is the functionally significant form of MCP-1, MCP-2 and MCP-3.

About this Structure

1BO0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural characterization of a monomeric chemokine: monocyte chemoattractant protein-3., Kim KS, Rajarathnam K, Clark-Lewis I, Sykes BD, FEBS Lett. 1996 Oct 21;395(2-3):277-82. PMID:8898111 Page seeded by OCA on Fri May 2 11:45:08 2008

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