5f5r

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'''Unreleased structure'''
 
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The entry 5f5r is ON HOLD until Paper Publication
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==TRAP1N-ADPNP==
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<StructureSection load='5f5r' size='340' side='right' caption='[[5f5r]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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Authors: Tsai, F.T.F., Lee, S., Sung, N., Lee, J., Chang, C., Joachimiak, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5f5r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5F5R OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5F5R FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5f3k|5f3k]]</td></tr>
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[[Category: Sung, N]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5f5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5f5r OCA], [http://pdbe.org/5f5r PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5f5r RCSB], [http://www.ebi.ac.uk/pdbsum/5f5r PDBsum]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRAP1_HUMAN TRAP1_HUMAN]] Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.<ref>PMID:23525905</ref> <ref>PMID:23564345</ref> <ref>PMID:23747254</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chang, C]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak, A]]
[[Category: Lee, J]]
[[Category: Lee, J]]
[[Category: Lee, S]]
[[Category: Lee, S]]
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[[Category: Tsai, F.T.F]]
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[[Category: Sung, N]]
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[[Category: Chang, C]]
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[[Category: Tsai, F T.F]]
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[[Category: Atpase]]
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[[Category: Chaperone]]
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[[Category: Ghkl atpase]]

Revision as of 15:26, 2 March 2016

TRAP1N-ADPNP

5f5r, resolution 1.85Å

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