5fbk
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the extracellular domain of human calcium sensing receptor== | |
| - | + | <StructureSection load='5fbk' size='340' side='right' caption='[[5fbk]], [[Resolution|resolution]] 2.10Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fbk]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FBK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FBK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=TCR:CYCLOMETHYLTRYPTOPHAN'>TCR</scene></td></tr> | |
| - | [[Category: | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fbh|5fbh]]</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fbk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fbk OCA], [http://pdbe.org/5fbk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fbk RCSB], [http://www.ebi.ac.uk/pdbsum/5fbk PDBsum]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/CASR_HUMAN CASR_HUMAN]] Autosomal dominant hypocalcemia;Familial isolated hypoparathyroidism due to impaired PTH secretion;Neonatal severe primary hyperparathyroidism;Familial hypocalciuric hypercalcemia type 1;Bartter syndrome with hypocalcemia. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. Disease susceptibility is associated with variations affecting the gene represented in this entry. Homozygous defects in CASR can be a cause of primary hyperparathyroidism in adulthood. Patients suffer from osteoporosis and renal calculi, have marked hypercalcemia and increased serum PTH concentrations. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CASR_HUMAN CASR_HUMAN]] Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Brown, E M]] | ||
| + | [[Category: Hu, J]] | ||
| + | [[Category: Miller, C L]] | ||
| + | [[Category: Moremen, K W]] | ||
| + | [[Category: Yang, J J]] | ||
| + | [[Category: Zhang, C]] | ||
[[Category: Zhang, T]] | [[Category: Zhang, T]] | ||
| - | [[Category: Yang, J.J]] | ||
| - | [[Category: Brown, E.M]] | ||
| - | [[Category: Miller, C.L]] | ||
| - | [[Category: Moremen, K.W]] | ||
| - | [[Category: Hu, J]] | ||
[[Category: Zou, J]] | [[Category: Zou, J]] | ||
| - | [[Category: | + | [[Category: Ectodomain]] |
| + | [[Category: G-protein coupled receptor]] | ||
| + | [[Category: Membrane protein]] | ||
| + | [[Category: Signaling protein]] | ||
Revision as of 23:26, 23 June 2016
Crystal structure of the extracellular domain of human calcium sensing receptor
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