Erythropoietin receptor
From Proteopedia
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== Relevance == | == Relevance == | ||
| - | EpoR rescues red blood cells progenitors from apoptosis. | + | EpoR rescues red blood cells progenitors from apoptosis. Beneficial mutations of EpoR result in increase of red blood cell number and hence better athletic performance. |
== Disease == | == Disease == | ||
| + | |||
| + | Mutations in EpoR are the cause of erythroleukemia and erythrocytosis. | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 14:43, 20 January 2016
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3D Structures of erythropoietin receptor
Updated on 20-January-2016
1ern – hEpoR extracellular domain - human
2mv6 – hEpoR transmembrane domain - NMR
1ebp, 1eba – hEpoR extracellular domain + Epo peptide
1cn4, 1eer – hEpoR extracellular domain (mutant) + Epo (mutant)
2jix – hEpoR extracellular domain + antibody
4y5x, 4y5v – hEpoR extracellular domain + diabody
References
- ↑ Youssoufian H, Longmore G, Neumann D, Yoshimura A, Lodish HF. Structure, function, and activation of the erythropoietin receptor. Blood. 1993 May 1;81(9):2223-36. PMID:8481505
