5fsm

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'''Unreleased structure'''
 
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The entry 5fsm is ON HOLD
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==MTH1 substrate recognition: Complex with a methylbenzimidazolyl acetamide.==
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<StructureSection load='5fsm' size='340' side='right' caption='[[5fsm]], [[Resolution|resolution]] 1.67&Aring;' scene=''>
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Authors: Nissink, J.W.M., Bista, M., Breed, J., Carter, N., Embrey, K., Read, J., Phillips, C., Winter, J.J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5fsm]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FSM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FSM FirstGlance]. <br>
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Description: MTH1 substrate recognition: Complex with a methylbenzimidazolyl acetamide.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=N91:N-(1-METHYLBENZIMIDAZOL-5-YL)ACETAMIDE'>N91</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fsi|5fsi]], [[5fsk|5fsk]], [[5fsl|5fsl]], [[5fsn|5fsn]], [[5fso|5fso]]</td></tr>
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[[Category: Winter, J.J]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fsm OCA], [http://pdbe.org/5fsm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fsm RCSB], [http://www.ebi.ac.uk/pdbsum/5fsm PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fsm ProSAT]</span></td></tr>
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[[Category: Nissink, J.W.M]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/8ODP_HUMAN 8ODP_HUMAN]] Antimutagenic. Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress. Hydrolyzes 8-oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates into DNA and subsequently preventing A:T to C:G and G:C to T:A transversions. Able to hydrolyze also the corresponding ribonucleotides, 2-OH-ATP, 8-oxo-GTP and 8-oxo-ATP.<ref>PMID:10373420</ref> <ref>PMID:10608900</ref> <ref>PMID:11139615</ref> <ref>PMID:12857738</ref> <ref>PMID:22556419</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Bista, M]]
[[Category: Bista, M]]
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[[Category: Breed, J]]
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[[Category: Carter, N]]
[[Category: Embrey, K]]
[[Category: Embrey, K]]
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[[Category: Carter, N]]
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[[Category: Nissink, J W.M]]
[[Category: Phillips, C]]
[[Category: Phillips, C]]
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[[Category: Breed, J]]
 
[[Category: Read, J]]
[[Category: Read, J]]
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[[Category: Winter, J J]]
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[[Category: Hydrolase]]
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[[Category: Nudt1]]

Revision as of 15:32, 26 July 2016

MTH1 substrate recognition: Complex with a methylbenzimidazolyl acetamide.

5fsm, resolution 1.67Å

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