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Fibroblast growth factor

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<StructureSection load='2uus' size='350' side='right' scene='' caption='Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code [[2uus]]) '>
<StructureSection load='2uus' size='350' side='right' scene='' caption='Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code [[2uus]]) '>
== Function ==
== Function ==
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'''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family<ref>PMID:8747466</ref>. <br />
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'''Fibroblast growth factors''' (FGF) are involved in angiogenesis, wound-healing and embryonic development. FGF is heparin-binding protein. FGF require heparan sulfate (HS) to activate the four FGF cell-surface receptors (FGFR). In vertebrates there are 23 members in the FGF family<ref>PMID:11276432</ref>. <br />
* '''FGF1''' is called acidic FGF.<br />
* '''FGF1''' is called acidic FGF.<br />
* '''FGF2''' is called basic FGF.<br />
* '''FGF2''' is called basic FGF.<br />
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== Relevance ==
== Relevance ==
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FGF signaling is important in the pathogenesis of a variety of tumor types.
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FGF signaling is important in the pathogenesis of a variety of tumor types, angiogenesis and wound healing.
</StructureSection>
</StructureSection>

Revision as of 22:29, 21 January 2016

Rat fibroblast growth factor 1 complex with heparan sulfate (PDB code 2uus)

Drag the structure with the mouse to rotate

3D structures of fibroblast growth factor

Updated on 21-January-2016

References

  1. ↑ Ornitz DM, Itoh N. Fibroblast growth factors. Genome Biol. 2001;2(3):REVIEWS3005. Epub 2001 Mar 9. PMID:11276432

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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