Monocyte chemoattractant protein
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Human synthetic monocyte chemoattractant protein 1 (MCP)''' belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The gene for CCL2 is on chromosome 17 in region 17q11.2-q12. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines. The CCL2<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand | + | '''Human synthetic monocyte chemoattractant protein 1 (MCP)''' belongs to the superfamily of chemokines, which are proteins involved in immunoregulatory and inflammatory processes. The gene for CCL2 is on chromosome 17 in region 17q11.2-q12. The superfamily can be subdivided into 4 smaller groups, depending on the N-ter arangment of the cysteines. The CCL2<ref>PMID:8170963</ref> is also known as '''chemokine (C-C motif) ligand''' or: |
- MCP1 | - MCP1 | ||
- small inducible cytokine A2 (SCYA2) | - small inducible cytokine A2 (SCYA2) | ||
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== Disease == | == Disease == | ||
| - | CCL2 is implicated in several diseases like psoriasis, | + | CCL2 is implicated in several diseases like psoriasis, atherosclerosis and rheumatoid arthritis where the appear to recruit macrophages, therefore bolstering the inflammation on joints. |
| - | + | CCL2 has also been found elevated in the urine of people with lupus as a sign warning of inflammation of the kidney. | |
| - | + | CCL2 is overexpressed in epilepsy, brain ischemia, Alzheimer's disease, EAE and traumatic brain injury. | |
== Relevance == | == Relevance == | ||
| - | + | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 13:07, 26 January 2016
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3D structures of Monocyte chemoattractant protein
Updated on 26-January-2016
References
https://fr.wikipedia.org/wiki/CCL2 http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK http://www.uniprot.org/uniprot/P13500#interaction http://www.rcsb.org/pdb/explore/explore.do?structureId=3IFD
- ↑ Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6. PMID:8170963
- ↑ Lubkowski J, Bujacz G, Boque L, Domaille PJ, Handel TM, Wlodawer A. The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions. Nat Struct Biol. 1997 Jan;4(1):64-9. PMID:8989326
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Coline Perrin, Alexane Caignard, Michal Harel, Alexander Berchansky, Joel L. Sussman
