This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
Monocyte chemoattractant protein
From Proteopedia
| Line 20: | Line 20: | ||
== Disease == | == Disease == | ||
| - | CCL2 is implicated in several diseases like psoriasis | + | CCL2 is implicated in several diseases like psoriasis and rheumatoid arthritis where the appear to recruit macrophages, therefore bolstering the inflammation on joints. |
| - | + | It is thought to be involved in atherosclerosis in the recruitment of monocytes into the arterial wall. | |
| + | It has also been found elevated in the urine of people with lupus as a sign warning of inflammation of the kidney. | ||
CCL2 is overexpressed in epilepsy, brain ischemia, Alzheimer's disease, EAE and traumatic brain injury. | CCL2 is overexpressed in epilepsy, brain ischemia, Alzheimer's disease, EAE and traumatic brain injury. | ||
| - | |||
| - | == Relevance == | ||
| - | |||
| - | |||
== Structural highlights == | == Structural highlights == | ||
Revision as of 13:11, 26 January 2016
| |||||||||||
3D structures of Monocyte chemoattractant protein
Updated on 26-January-2016
References
https://fr.wikipedia.org/wiki/CCL2 http://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/pdbsum/GetPage.pl?pdbcode=1DOK http://www.uniprot.org/uniprot/P13500#interaction http://www.rcsb.org/pdb/explore/explore.do?structureId=3IFD
- ↑ Carr MW, Roth SJ, Luther E, Rose SS, Springer TA. Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant. Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6. PMID:8170963
- ↑ Lubkowski J, Bujacz G, Boque L, Domaille PJ, Handel TM, Wlodawer A. The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions. Nat Struct Biol. 1997 Jan;4(1):64-9. PMID:8989326
Proteopedia Page Contributors and Editors (what is this?)
Coline Perrin, Alexane Caignard, Michal Harel, Alexander Berchansky, Joel L. Sussman
