Calcium uptake protein 1
From Proteopedia
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==Your Heading Here (maybe something like 'Structure')== | ==Your Heading Here (maybe something like 'Structure')== | ||
<StructureSection load='4NSC' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='4NSC' size='340' side='right' caption='Caption for this structure' scene=''> | ||
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| - | + | Micu 1 (Mitochondrial Calcium Uptake 1) is a key regulator of mitochondrial calcium uniporter (MCU) required to increase calcium uptake by MCU when cytoplasmic calcium is high. | |
| + | It also regulates glucose-dependent insulin secretion in pancreatic beta-cells by regulating mitochondrial calcium uptake. | ||
== Function == | == Function == | ||
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| + | Micu 1 is a regulator of Ca 2+ uptakes in mitochondria. | ||
| + | It mainly acts on MCU when linked to MICU2 (paralogues). | ||
| + | When in an hexameric conformation : Micu 1 silences the activity of MCU/EMRE and so stop the Ca 2+ from entering the mitochondria. | ||
| + | When the calcium of the intermembrane binds to MICU1 and MICU2 they change their conformation and open the “gate” in front of the MCU channel and let the calcium enter into the matrix. | ||
== Disease == | == Disease == | ||
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| + | The major disease linked to a dysfunctional Micu 1 protein is myopathy with extrapyramidal signs (MPXPS). | ||
| + | But other diseases can be observed like : ataxia, microcephaly, ophthalmoplegia, ptosis, optic atrophy and axonal peripheral neuropathy | ||
== Relevance == | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
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| + | Ca 2+ binds to EF domain on MICU 1 and 2 | ||
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
Revision as of 16:28, 27 January 2016
Your Heading Here (maybe something like 'Structure')
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