1buw

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[[Image:1buw.jpg|left|200px]]
[[Image:1buw.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1buw |SIZE=350|CAPTION= <scene name='initialview01'>1buw</scene>, resolution 1.9&Aring;
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The line below this paragraph, containing "STRUCTURE_1buw", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=NO:NITROGEN+OXIDE'>NO</scene>, <scene name='pdbligand=SNC:S-NITROSO-CYSTEINE'>SNC</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1buw| PDB=1buw | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1buw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1buw OCA], [http://www.ebi.ac.uk/pdbsum/1buw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1buw RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A'''
'''CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A'''
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[[Category: Chan, N L.]]
[[Category: Chan, N L.]]
[[Category: Rogers, P H.]]
[[Category: Rogers, P H.]]
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[[Category: oxygen transport and vasodilation]]
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[[Category: Oxygen transport and vasodilation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 11:58:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:08:47 2008''
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Revision as of 08:59, 2 May 2008

Image:1buw.jpg

Template:STRUCTURE 1buw

CRYSTAL STRUCTURE OF S-NITROSO-NITROSYL HUMAN HEMOGLOBIN A


Overview

Although numerous reports have documented that the S-nitrosylation of cysteine residues by NO alters the activities of a wide variety of proteins, the direct visualization and the structural consequences of this reversible modification have not yet been reported for any protein. Here we describe the crystal structure of S-nitroso-nitrosylhemoglobin determined at a resolution of 1.8 A. The specific reaction of NO with Cys93beta is confirmed in this structure, and a large S-nitrosylation-induced change in the tertiary structure of the COOH-terminal dipeptides of the beta subunits provides additional insight into the stereochemical mechanism by which blood flow is regulated by the interaction of NO with hemoglobin.

About this Structure

1BUW is a Protein complex structure of sequences from Homo sapiens. The following page contains interesting information on the relation of 1BUW with [Hemoglobin]. Full crystallographic information is available from OCA.

Reference

Crystal structure of the S-nitroso form of liganded human hemoglobin., Chan NL, Rogers PH, Arnone A, Biochemistry. 1998 Nov 24;37(47):16459-64. PMID:9843411 Page seeded by OCA on Fri May 2 11:58:59 2008

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