Sandbox Reserved 1127

This is a default text for your page '. Click above on edit this page' to modify. Be careful with the < and > signs.

You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Function

PDE5 is an phosphodiesterase : this enzyme catalyzes the hydrolysis of cGMP into 5'GMP. CGMP is an usual second messager in cell transduction. PDE5 regulates its concentration by hydrolysis. Human PDE5 is a PDE of class I.

Disease

If an inhibitor binds instead of cGMP, cGMP concentration increases and the stimulus continues. PDE5 inhibition is particulary used for erectile disfunction. Sildenafil or VIagra is an inhibitor of PDE5.

Relevance

Structural highlights

PDE5 is a dimeric protein of about 270 amino acids long. The C terminal has the catalytic domain and two Zn2+ binding site and N temrinal is the regulatory domain which includes two the GAF domain a and b. There are thus plural allosteric binding site for cGMP in the Cterminal and the N terminal. cGAMP binds on Gap a allosteric site and promotes the phosphorylation of SER 92 of PKG. This phosphorylation increases the affinity betwezen cGMP and PDE5 : another cGMP binds to the Gapb which allows the activation of the catalytic site of PDE5.  :http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2518390/)

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.