1bvk

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[[Image:1bvk.gif|left|200px]]
[[Image:1bvk.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1bvk |SIZE=350|CAPTION= <scene name='initialview01'>1bvk</scene>, resolution 2.7&Aring;
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The line below this paragraph, containing "STRUCTURE_1bvk", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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{{STRUCTURE_1bvk| PDB=1bvk | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bvk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bvk OCA], [http://www.ebi.ac.uk/pdbsum/1bvk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bvk RCSB]</span>
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}}
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'''HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME'''
'''HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME'''
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[[Category: Foote, J.]]
[[Category: Foote, J.]]
[[Category: Holmes, M A.]]
[[Category: Holmes, M A.]]
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[[Category: anti-lysozyme]]
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[[Category: Anti-lysozyme]]
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[[Category: antibody complex]]
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[[Category: Antibody complex]]
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[[Category: complex (humanized antibody/hydrolase)]]
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[[Category: Fv]]
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[[Category: fv]]
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[[Category: Humanized antibody]]
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[[Category: humanized antibody]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:00:24 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:09:05 2008''
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Revision as of 09:00, 2 May 2008

Image:1bvk.gif

Template:STRUCTURE 1bvk

HUMANIZED ANTI-LYSOZYME FV COMPLEXED WITH LYSOZYME


Overview

The crystal structure of the complex between hen egg lysozyme and the Fv fragment of a humanized antilysozyme antibody was determined to 2.7-A resolution. The structure of the antigen combining site in the complex is nearly identical to that of the complexed form of the parent mouse antibody, D1.3. In contrast, the combining sites of the unliganded mouse and humanized antilysozymes show moderate conformational differences. This disparity suggests that a conformational readjustment process linked to antigen binding reverses adverse conformations in the complementarity determining regions that had been introduced by engineering these segments next to human framework regions in the humanized antibody.

About this Structure

1BVK is a Protein complex structure of sequences from Gallus gallus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Conformational correction mechanisms aiding antigen recognition by a humanized antibody., Holmes MA, Buss TN, Foote J, J Exp Med. 1998 Feb 16;187(4):479-85. PMID:9463398 Page seeded by OCA on Fri May 2 12:00:24 2008

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