1w8b

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[[Category: serine protease]]
[[Category: serine protease]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 15:07:31 2007''
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 17:28:47 2007''

Revision as of 15:23, 5 November 2007

Image:1w8b.gif

1w8b, resolution 3.00Å

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FACTOR7- 413 COMPLEX

Overview

We describe the structure-based design and synthesis of highly potent, orally bioavailable tissue factor/factor VIIa inhibitors which interfere, with the coagulation cascade by selective inhibition of the extrinsic, pathway.

About this Structure

1W8B is a Protein complex structure of sequences from Homo sapiens with CA and 413 as ligands. Active as Coagulation factor VIIa, with EC number 3.4.21.21 Structure known Active Site: AC1. Full crystallographic information is available from OCA.

Reference

Selective and orally bioavailable phenylglycine tissue factor/factor VIIa inhibitors., Zbinden KG, Obst-Sander U, Hilpert K, Kuhne H, Banner DW, Bohm HJ, Stahl M, Ackermann J, Alig L, Weber L, Wessel HP, Riederer MA, Tschopp TB, Lave T, Bioorg Med Chem Lett. 2005 Dec 1;15(23):5344-52. Epub 2005 Oct 4. PMID:16213138

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