1bvj

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[[Image:1bvj.gif|left|200px]]
[[Image:1bvj.gif|left|200px]]
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{{Structure
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bvj OCA], [http://www.ebi.ac.uk/pdbsum/1bvj PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bvj RCSB]</span>
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'''HIV-1 RNA A-RICH HAIRPIN LOOP'''
'''HIV-1 RNA A-RICH HAIRPIN LOOP'''
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[[Category: Puglisi, E V.]]
[[Category: Puglisi, E V.]]
[[Category: Puglisi, J D.]]
[[Category: Puglisi, J D.]]
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[[Category: hiv-1 genomic rna]]
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[[Category: Hiv-1 genomic rna]]
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[[Category: reverse transcriptase initiation]]
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[[Category: Reverse transcriptase initiation]]
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[[Category: rna hairpin loop]]
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[[Category: Rna hairpin loop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:00:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:09:08 2008''
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Revision as of 09:00, 2 May 2008

Image:1bvj.gif

Template:STRUCTURE 1bvj

HIV-1 RNA A-RICH HAIRPIN LOOP


Overview

Interaction of HIV-1 genomic RNA and human tRNA(Lys)3 initiates viral reverse transcription. An adenosine-rich (A-rich) loop in HIV RNA mediates complex formation between tRNA and viral RNA. We have determined the structure of an A-rich loop oligonucleotide using nuclear magnetic resonance spectroscopy. The loop structure is stabilized by a noncanonical G-A pair and a U-turn motif, which leads to stacking of the conserved adenosines. The structure has similarity to the tRNA anticodon structure, and suggests possible mechanisms for its role in initiation of reverse transcription.

About this Structure

1BVJ is a Single protein structure of sequence from Human immunodeficiency virus 1. Full crystallographic information is available from OCA.

Reference

HIV-1 A-rich RNA loop mimics the tRNA anticodon structure., Puglisi EV, Puglisi JD, Nat Struct Biol. 1998 Dec;5(12):1033-6. PMID:9846871 Page seeded by OCA on Fri May 2 12:00:08 2008

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