1bwm

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{{Structure
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The line below this paragraph, containing "STRUCTURE_1bwm", creates the "Structure Box" on the page.
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bwm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bwm OCA], [http://www.ebi.ac.uk/pdbsum/1bwm PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bwm RCSB]</span>
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'''A SINGLE-CHAIN T CELL RECEPTOR'''
'''A SINGLE-CHAIN T CELL RECEPTOR'''
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[[Category: Wagner, G.]]
[[Category: Wagner, G.]]
[[Category: Wyss, D F.]]
[[Category: Wyss, D F.]]
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[[Category: immunoglobulin]]
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[[Category: Immunoglobulin]]
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[[Category: immunoreceptor]]
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[[Category: Immunoreceptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:02:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:09:41 2008''
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Revision as of 09:02, 2 May 2008

Image:1bwm.gif

Template:STRUCTURE 1bwm

A SINGLE-CHAIN T CELL RECEPTOR


Overview

Using NMR spectroscopy, we determined the solution structure of a single-chain T-cell receptor (scTCR) derived from the major histocompatibility complex (MHC) class II-restricted D10 TCR. The conformations of complementarity-determining regions (CDRs) 3beta and 1alpha and surface properties of 2alpha are different from those of related class I-restricted TCRs. We infer a conserved orientation for TCR V(alpha) domains in complexes with both class I and II MHC-peptide ligands, which implies that small structural variations in V(alpha) confer MHC class preference. High mobility of CDR3 residues relative to other CDR or framework residues (picosecond time scale) provides insight into immune recognition and selection mechanisms.

About this Structure

1BWM is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor., Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G, Nat Struct Biol. 1999 Jun;6(6):574-81. PMID:10360364 Page seeded by OCA on Fri May 2 12:02:39 2008

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