1bxd

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1bxd.gif|left|200px]]
[[Image:1bxd.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1bxd |SIZE=350|CAPTION= <scene name='initialview01'>1bxd</scene>
+
The line below this paragraph, containing "STRUCTURE_1bxd", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1bxd| PDB=1bxd | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bxd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bxd OCA], [http://www.ebi.ac.uk/pdbsum/1bxd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bxd RCSB]</span>
+
-
}}
+
'''NMR STRUCTURE OF THE HISTIDINE KINASE DOMAIN OF THE E. COLI OSMOSENSOR ENVZ'''
'''NMR STRUCTURE OF THE HISTIDINE KINASE DOMAIN OF THE E. COLI OSMOSENSOR ENVZ'''
Line 40: Line 37:
[[Category: Tong, K I.]]
[[Category: Tong, K I.]]
[[Category: Yamazaki, T.]]
[[Category: Yamazaki, T.]]
-
[[Category: his-asp phosphorelay system]]
+
[[Category: His-asp phosphorelay system]]
-
[[Category: histidine kinase]]
+
[[Category: Histidine kinase]]
-
[[Category: osmosensor]]
+
[[Category: Osmosensor]]
-
[[Category: signal transduction]]
+
[[Category: Signal transduction]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:04:32 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:10:13 2008''
+

Revision as of 09:04, 2 May 2008

Image:1bxd.gif

Template:STRUCTURE 1bxd

NMR STRUCTURE OF THE HISTIDINE KINASE DOMAIN OF THE E. COLI OSMOSENSOR ENVZ


Overview

Bacteria live in capricious environments, in which they must continuously sense external conditions in order to adjust their shape, motility and physiology. The histidine-aspartate phosphorelay signal-transduction system (also known as the two-component system) is important in cellular adaptation to environmental changes in both prokaryotes and lower eukaryotes. In this system, protein histidine kinases function as sensors and signal transducers. The Escherichia coli osmosensor, EnvZ, is a transmembrane protein with histidine kinase activity in its cytoplasmic region. The cytoplasmic region contains two functional domains: domain A (residues 223-289) contains the conserved histidine residue (H243), a site of autophosphorylation as well as transphosphorylation to the conserved D55 residue of response regulator OmpR, whereas domain B (residues 290-450) encloses several highly conserved regions (G1, G2, F and N boxes) and is able to phosphorylate H243. Here we present the solution structure of domain B, the catalytic core of EnvZ. This core has a novel protein kinase structure, distinct from the serine/threonine/tyrosine kinase fold, with unanticipated similarities to both heatshock protein 90 and DNA gyrase B.

About this Structure

1BXD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

NMR structure of the histidine kinase domain of the E. coli osmosensor EnvZ., Tanaka T, Saha SK, Tomomori C, Ishima R, Liu D, Tong KI, Park H, Dutta R, Qin L, Swindells MB, Yamazaki T, Ono AM, Kainosho M, Inouye M, Ikura M, Nature. 1998 Nov 5;396(6706):88-92. PMID:9817206 Page seeded by OCA on Fri May 2 12:04:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1bxd"
Personal tools