1bxl
From Proteopedia
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'''STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE''' | '''STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE''' | ||
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[[Category: Thompson, C B.]] | [[Category: Thompson, C B.]] | ||
[[Category: Yoon, H.]] | [[Category: Yoon, H.]] | ||
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| - | [[Category: | + | [[Category: Apoptosis]] |
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Revision as of 09:05, 2 May 2008
STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
Heterodimerization between members of the Bcl-2 family of proteins is a key event in the regulation of programmed cell death. The molecular basis for heterodimer formation was investigated by determination of the solution structure of a complex between the survival protein Bcl-xL and the death-promoting region of the Bcl-2-related protein Bak. The structure and binding affinities of mutant Bak peptides indicate that the Bak peptide adopts an amphipathic alpha helix that interacts with Bcl-xL through hydrophobic and electrostatic interactions. Mutations in full-length Bak that disrupt either type of interaction inhibit the ability of Bak to heterodimerize with Bcl-xL.
About this Structure
1BXL is a Protein complex structure of sequences from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis., Sattler M, Liang H, Nettesheim D, Meadows RP, Harlan JE, Eberstadt M, Yoon HS, Shuker SB, Chang BS, Minn AJ, Thompson CB, Fesik SW, Science. 1997 Feb 14;275(5302):983-6. PMID:9020082 Page seeded by OCA on Fri May 2 12:05:00 2008
