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5hmo

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m (Protected "5hmo" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 5hmo is ON HOLD until Paper Publication
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==myosin X motor activity==
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<StructureSection load='5hmo' size='340' side='right' caption='[[5hmo]], [[Resolution|resolution]] 3.49&Aring;' scene=''>
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Authors: Ropars, V., Blanc, F., Samazan, F., Houdusse, A.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hmo]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HMO OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HMO FirstGlance]. <br>
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Description: myosin X motor activity
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hmo OCA], [http://pdbe.org/5hmo PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hmo RCSB], [http://www.ebi.ac.uk/pdbsum/5hmo PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hmo ProSAT]</span></td></tr>
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[[Category: Unreleased Structures]]
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/MYO10_BOVIN MYO10_BOVIN]] In hippocampal neurons it induces the formation of dendritic filopodia by trafficking the actin-remodeling protein VASP to the tips of filopodia, where it promotes actin elongation (By similarity). Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. MYO10 binds to actin filaments and actin bundles and functions as plus end-directed motor. The tail domain binds to membranous compartments containing phosphatidylinositol 3,4,5-trisphosphate, which are then moved relative to actin filaments. Stimulates the formation and elongation of filopodia. Regulates cell shape, cell spreading and cell adhesion. Plays a role in formation of the podosome belt in osteoclasts.<ref>PMID:11457842</ref> <ref>PMID:15156152</ref> <ref>PMID:15705568</ref> <ref>PMID:16894163</ref> <ref>PMID:20081229</ref> <ref>PMID:20364131</ref> <ref>PMID:20392702</ref> <ref>PMID:20930142</ref> <ref>PMID:21666676</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Blanc, F]]
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[[Category: Houdusse, A]]
[[Category: Ropars, V]]
[[Category: Ropars, V]]
[[Category: Samazan, F]]
[[Category: Samazan, F]]
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[[Category: Blanc, F]]
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[[Category: Motor protein]]
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[[Category: Houdusse, A]]
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[[Category: Myosin]]

Revision as of 21:07, 10 September 2016

myosin X motor activity

5hmo, resolution 3.49Å

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