1by4

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[[Image:1by4.gif|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=DA:2&#39;-DEOXYADENOSINE-5&#39;-MONOPHOSPHATE'>DA</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1by4| PDB=1by4 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1by4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1by4 OCA], [http://www.ebi.ac.uk/pdbsum/1by4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1by4 RCSB]</span>
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'''STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA'''
'''STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA'''
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[[Category: Sigler, P B.]]
[[Category: Sigler, P B.]]
[[Category: Zhao, Q.]]
[[Category: Zhao, Q.]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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[[Category: hormone response element]]
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[[Category: Hormone response element]]
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[[Category: nuclear receptor]]
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[[Category: Nuclear receptor]]
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[[Category: protein-dna interation]]
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[[Category: Protein-dna interation]]
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[[Category: rxr]]
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[[Category: Rxr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:06:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:10:44 2008''
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Revision as of 09:06, 2 May 2008

Image:1by4.gif

Template:STRUCTURE 1by4

STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA


Overview

The 9-cis retinoic acid receptor, RXR, binds DNA effectively as a homodimer or as a heterodimer with other nuclear receptors. The DNA-binding sites for these RXR complexes are direct repeats of a consensus sequence separated by one to five base-pairs of intervening space. Here, we report the 2.1 A crystal structure of the RXR-DNA-binding domain as a homodimer in complex with its idealized direct repeat DNA target. The structure shows how a gene-regulatory site can induce conformational changes in a transcription factor that promote homo-cooperative assembly. Specifically, an alpha-helix in the T-box is disrupted to allow efficient DNA-binding and subunit dimerization. RXR displays a relaxed mode of sequence recognition, interacting with only three base-pairs in each hexameric half-site. The structure illustrates how site selection is achieved in this large eukaryotic transcription factor family through discrete protein-protein interactions and the use of tandem DNA binding sites with characteristic spacings.

About this Structure

1BY4 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of RXR-DNA interactions., Zhao Q, Chasse SA, Devarakonda S, Sierk ML, Ahvazi B, Rastinejad F, J Mol Biol. 2000 Feb 18;296(2):509-20. PMID:10669605 Page seeded by OCA on Fri May 2 12:06:18 2008

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