1bys

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[[Image:1bys.jpg|left|200px]]
[[Image:1bys.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1bys |SIZE=350|CAPTION= <scene name='initialview01'>1bys</scene>, resolution 2.0&Aring;
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The line below this paragraph, containing "STRUCTURE_1bys", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=ACT:Residues+From+Both+Monomers+Create+The+Active+Site'>ACT</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=WO4:TUNGSTATE(VI)ION'>WO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= NUC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=602 Salmonella typhimurium])
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-->
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|DOMAIN=
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{{STRUCTURE_1bys| PDB=1bys | SCENE= }}
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|RELATEDENTRY=[[1byr|1BYR]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1bys FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1bys OCA], [http://www.ebi.ac.uk/pdbsum/1bys PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1bys RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF NUC COMPLEXED WITH TUNGSTATE'''
'''CRYSTAL STRUCTURE OF NUC COMPLEXED WITH TUNGSTATE'''
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[[Category: Dixon, J E.]]
[[Category: Dixon, J E.]]
[[Category: Stuckey, J A.]]
[[Category: Stuckey, J A.]]
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[[Category: endonuclease]]
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[[Category: Endonuclease]]
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[[Category: phosphodiesterase]]
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[[Category: Phosphodiesterase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:07:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:11:04 2008''
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Revision as of 09:07, 2 May 2008

Image:1bys.jpg

Template:STRUCTURE 1bys

CRYSTAL STRUCTURE OF NUC COMPLEXED WITH TUNGSTATE


Overview

The first crystal structure of a phospholipase D (PLD) family member has been determined at 2.0 A resolution. The PLD superfamily is defined by a common sequence motif, HxK(x)4D(x)6GSxN, and includes enzymes involved in signal transduction, lipid biosynthesis, endonucleases and open reading frames in pathogenic viruses and bacteria. The crystal structure suggests that residues from two sequence motifs form a single active site. A histidine residue from one motif acts as a nucleophile in the catalytic mechanism, forming a phosphoenzyme intermediate, whereas a histidine residue from the other motif appears to function as a general acid in the cleavage of the phosphodiester bond. The structure suggests that the conserved lysine residues are involved in phosphate binding. Large-scale genomic sequencing revealed that there are many PLD family members. Our results suggest that all of these proteins may possess a common structure and catalytic mechanism.

About this Structure

1BYS is a Single protein structure of sequence from Salmonella typhimurium. Full crystallographic information is available from OCA.

Reference

Crystal structure of a phospholipase D family member., Stuckey JA, Dixon JE, Nat Struct Biol. 1999 Mar;6(3):278-84. PMID:10074947 Page seeded by OCA on Fri May 2 12:07:45 2008

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