1byx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1byx.gif|left|200px]]
[[Image:1byx.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1byx |SIZE=350|CAPTION= <scene name='initialview01'>1byx</scene>
+
The line below this paragraph, containing "STRUCTURE_1byx", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=DC:2&#39;-DEOXYCYTIDINE-5&#39;-MONOPHOSPHATE'>DC</scene>, <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1byx| PDB=1byx | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1byx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1byx OCA], [http://www.ebi.ac.uk/pdbsum/1byx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1byx RCSB]</span>
+
-
}}
+
'''CHIMERIC HYBRID DUPLEX R(GCAGUGGC).R(GCCA)D(CTGC) COMPRISING THE TRNA-DNA JUNCTION FORMED DURING INITIATION OF HIV-1 REVERSE TRANSCRIPTION'''
'''CHIMERIC HYBRID DUPLEX R(GCAGUGGC).R(GCCA)D(CTGC) COMPRISING THE TRNA-DNA JUNCTION FORMED DURING INITIATION OF HIV-1 REVERSE TRANSCRIPTION'''
Line 19: Line 16:
==About this Structure==
==About this Structure==
-
1BYX is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYX OCA].
+
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BYX OCA].
==Reference==
==Reference==
NMR structure of the chimeric hybrid duplex r(gcaguggc).r(gcca)d(CTGC) comprising the tRNA-DNA junction formed during initiation of HIV-1 reverse transcription., Szyperski T, Gotte M, Billeter M, Perola E, Cellai L, Heumann H, Wuthrich K, J Biomol NMR. 1999 Apr;13(4):343-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10353196 10353196]
NMR structure of the chimeric hybrid duplex r(gcaguggc).r(gcca)d(CTGC) comprising the tRNA-DNA junction formed during initiation of HIV-1 reverse transcription., Szyperski T, Gotte M, Billeter M, Perola E, Cellai L, Heumann H, Wuthrich K, J Biomol NMR. 1999 Apr;13(4):343-55. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10353196 10353196]
-
[[Category: Protein complex]]
 
[[Category: Billeter, M.]]
[[Category: Billeter, M.]]
[[Category: Cellai, L.]]
[[Category: Cellai, L.]]
Line 29: Line 25:
[[Category: Perola, E.]]
[[Category: Perola, E.]]
[[Category: Szyperski, T.]]
[[Category: Szyperski, T.]]
-
[[Category: reverse transcriptase]]
+
[[Category: Reverse transcriptase]]
-
[[Category: rna:rna-dna chimeric hybrid]]
+
[[Category: Rna:rna-dna chimeric hybrid]]
-
[[Category: rnase h]]
+
[[Category: Rnase h]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:07:58 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:11:12 2008''
+

Revision as of 09:07, 2 May 2008

Image:1byx.gif

Template:STRUCTURE 1byx

CHIMERIC HYBRID DUPLEX R(GCAGUGGC).R(GCCA)D(CTGC) COMPRISING THE TRNA-DNA JUNCTION FORMED DURING INITIATION OF HIV-1 REVERSE TRANSCRIPTION


Overview

A high-quality NMR solution structure of the chimeric hybrid duplex r(gcaguggc).r(gcca)d(CTGC) was determined using the program DYANA with its recently implemented new module FOUND, which performs exhaustive conformational grid searches for dinucleotides. To ensure conservative data interpretation, the use of 1H-1H lower distance limit constraints was avoided. The duplex comprises the tRNA-DNA junction formed during the initiation of HIV-1 reverse transcription. It forms an A-type double helix that exhibits distinct structural deviations from a standard A-conformation. In particular, the minor groove is remarkably narrow, and its width decreases from about 7.5 A in the RNA/RNA stem to about 4.5 A in the RNA/DNA segment. This is unexpected, since minor groove widths for A-RNA and RNA/DNA hybrid duplexes of approximately 11 A and approximately 8.5 A, respectively, were previously reported. The present, new structure supports that reverse transcriptase-associated RNaseH specificity is related primarily to conformational adaptability of the nucleic acid in 'induced-fit'-type interactions, rather than the minor groove width of a predominantly static nucleic acid duplex.

About this Structure

Full crystallographic information is available from OCA.

Reference

NMR structure of the chimeric hybrid duplex r(gcaguggc).r(gcca)d(CTGC) comprising the tRNA-DNA junction formed during initiation of HIV-1 reverse transcription., Szyperski T, Gotte M, Billeter M, Perola E, Cellai L, Heumann H, Wuthrich K, J Biomol NMR. 1999 Apr;13(4):343-55. PMID:10353196 Page seeded by OCA on Fri May 2 12:07:58 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1byx"
Personal tools