1c1e
From Proteopedia
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'''CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN''' | '''CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | The following page contains interesting information on the relation of 1C1E with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb21_1.html Antibodies]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C1E OCA]. | |
==Reference== | ==Reference== | ||
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template., Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA, Science. 1999 Dec 17;286(5448):2345-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10600746 10600746] | Evolution of shape complementarity and catalytic efficiency from a primordial antibody template., Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA, Science. 1999 Dec 17;286(5448):2345-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10600746 10600746] | ||
[[Category: Antibodies]] | [[Category: Antibodies]] | ||
| - | [[Category: Mus musculus]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Wilson, I A.]] | [[Category: Wilson, I A.]] | ||
[[Category: Xu, J.]] | [[Category: Xu, J.]] | ||
| - | [[Category: | + | [[Category: Catalytic antibody]] |
| - | [[Category: | + | [[Category: Diels-alder]] |
| - | [[Category: | + | [[Category: Immunoglobulin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:12:58 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:12, 2 May 2008
CRYSTAL STRUCTURE OF A DIELS-ALDERASE CATALYTIC ANTIBODY 1E9 IN COMPLEX WITH ITS HAPTEN
Overview
The crystal structure of an efficient Diels-Alder antibody catalyst at 1.9 angstrom resolution reveals almost perfect shape complementarity with its transition state analog. Comparison with highly related progesterone and Diels-Alderase antibodies that arose from the same primordial germ line template shows the relatively subtle mutational steps that were able to evolve both structural complementarity and catalytic efficiency.
About this Structure
The following page contains interesting information on the relation of 1C1E with [Antibodies]. Full crystallographic information is available from OCA.
Reference
Evolution of shape complementarity and catalytic efficiency from a primordial antibody template., Xu J, Deng Q, Chen J, Houk KN, Bartek J, Hilvert D, Wilson IA, Science. 1999 Dec 17;286(5448):2345-8. PMID:10600746 Page seeded by OCA on Fri May 2 12:12:58 2008
