1c5f

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[[Image:1c5f.gif|left|200px]]
[[Image:1c5f.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1c5f |SIZE=350|CAPTION= <scene name='initialview01'>1c5f</scene>, resolution 2.47&Aring;
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The line below this paragraph, containing "STRUCTURE_1c5f", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ABA:ALPHA-AMINOBUTYRIC+ACID'>ABA</scene>, <scene name='pdbligand=BMT:4-METHYL-4-[(E)-2-BUTENYL]-4,N-METHYL-THREONINE'>BMT</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=MVA:N-METHYLVALINE'>MVA</scene>, <scene name='pdbligand=SAR:SARCOSINE'>SAR</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= BMCYP-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=6279 Brugia malayi])
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-->
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|DOMAIN=
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{{STRUCTURE_1c5f| PDB=1c5f | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c5f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c5f OCA], [http://www.ebi.ac.uk/pdbsum/1c5f PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c5f RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A'''
'''CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A'''
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==About this Structure==
==About this Structure==
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1C5F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. This structure supersedes the now removed PDB entry 1QTL. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5F OCA].
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1C5F is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Brugia_malayi Brugia malayi]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1qtl 1qtl]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1C5F OCA].
==Reference==
==Reference==
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[[Category: Kuhn, P.]]
[[Category: Kuhn, P.]]
[[Category: Ma, D.]]
[[Category: Ma, D.]]
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[[Category: cyclosporin]]
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[[Category: Cyclosporin]]
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[[Category: isomerase]]
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[[Category: Isomerase]]
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[[Category: isomerase/immune system]]
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[[Category: Isomerase/immune system]]
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[[Category: peptidyl-prolyl cis-tran]]
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[[Category: Peptidyl-prolyl cis-tran]]
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[[Category: peptidylprolyl isomerase]]
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[[Category: Peptidylprolyl isomerase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:21:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:14:53 2008''
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Revision as of 09:21, 2 May 2008

Image:1c5f.gif

Template:STRUCTURE 1c5f

CRYSTAL STRUCTURE OF THE CYCLOPHILIN-LIKE DOMAIN FROM BRUGIA MALAYI COMPLEXED WITH CYCLOSPORIN A


Overview

The resistance of the human parasite Brugia malayi to the antiparasitic activity of cyclosporin A (CsA) may arise from the presence of cyclophilins with relatively low affinity for the drug. The structure of the complex of B. malayi cyclophilin (BmCYP-1) and CsA, with eight independent copies in the asymmetric unit, has been determined at a resolution of 2.7 A. The low affinity of BmCYP-1 for CsA arises from incomplete preorganization of the binding site so that the formation of a hydrogen bond between His132 of BmCYP-1 and N-methylleucine 9 of CsA is associated with a shift in the backbone of approximately 1 A in this region.

About this Structure

1C5F is a Single protein structure of sequence from Brugia malayi. This structure supersedes the now removed PDB entry 1qtl. Full crystallographic information is available from OCA.

Reference

Crystal structure of the complex of brugia malayi cyclophilin and cyclosporin A., Ellis PJ, Carlow CK, Ma D, Kuhn P, Biochemistry. 2000 Jan 25;39(3):592-8. PMID:10642184 Page seeded by OCA on Fri May 2 12:21:00 2008

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