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Gramicidin

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<Structure load='2xds' size='350' scene= caption='Gramicidin D dimer with formyl-valine, formyl-isoleucine complex with PEG 1500 and ethanolamine , [[2xdc]]'/>
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<Structure load='2xds' size='350' side=right scene= caption='Gramicidin D dimer with formyl-valine, formyl-isoleucine complex with PEG 1500 and ethanolamine , [[2xdc]]'/>
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== Function ==
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[[Gramicidin]] (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It has bactericidal activity and is used as antibiotic. It is produced by the bacteria ''Bacillus brevis''.<br />
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[[Gramicidin]] (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria ''Bacillus brevis''<ref>PMID:5288776</ref>.<br />
* '''GCDN S''' is an antibiotic cyclic polypeptide.<br />
* '''GCDN S''' is an antibiotic cyclic polypeptide.<br />
* '''GCDN D''' is a mixture of GCDN A, B, C. <br />
* '''GCDN D''' is a mixture of GCDN A, B, C. <br />
See theoretical model of [[Gramicidin Channel in Lipid Bilayer]].
See theoretical model of [[Gramicidin Channel in Lipid Bilayer]].
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==Relevance ==
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GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive<ref>PMID:8836773</ref>.
== 3D Structures of Gramicidin ==
== 3D Structures of Gramicidin ==

Revision as of 08:44, 16 March 2016

Gramicidin D dimer with formyl-valine, formyl-isoleucine complex with PEG 1500 and ethanolamine , 2xdc

Drag the structure with the mouse to rotate

Function

Gramicidin (GCDN) is a polypeptide composed of alternating L- and D-amino acids. It is produced by the bacteria Bacillus brevis[1].

  • GCDN S is an antibiotic cyclic polypeptide.
  • GCDN D is a mixture of GCDN A, B, C.

See theoretical model of Gramicidin Channel in Lipid Bilayer.

Relevance

GCDN has bactericidal activity and is used as a topical antibiotic and as topical contraceptive[2].

3D Structures of Gramicidin

Updated on 16-March-2016

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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