1c9e

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[[Image:1c9e.gif|left|200px]]
[[Image:1c9e.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1c9e |SIZE=350|CAPTION= <scene name='initialview01'>1c9e</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_1c9e", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MP1:N-METHYLMESOPORPHYRIN+CONTAINING+COPPER'>MP1</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ferrochelatase Ferrochelatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.99.1.1 4.99.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1c9e| PDB=1c9e | SCENE= }}
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|RELATEDENTRY=[[1ak1|1ak1]], [[1c1h|1c1h]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c9e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c9e OCA], [http://www.ebi.ac.uk/pdbsum/1c9e PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c9e RCSB]</span>
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}}
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'''STRUCTURE OF FERROCHELATASE WITH COPPER(II) N-METHYLMESOPORPHYRIN COMPLEX BOUND AT THE ACTIVE SITE'''
'''STRUCTURE OF FERROCHELATASE WITH COPPER(II) N-METHYLMESOPORPHYRIN COMPLEX BOUND AT THE ACTIVE SITE'''
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[[Category: Hansson, M.]]
[[Category: Hansson, M.]]
[[Category: Lecerof, D.]]
[[Category: Lecerof, D.]]
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[[Category: bacillus subtili]]
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[[Category: Bacillus subtili]]
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[[Category: chelatase]]
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[[Category: Chelatase]]
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[[Category: heme synthesis]]
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[[Category: Heme synthesis]]
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[[Category: lyase]]
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[[Category: Lyase]]
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[[Category: n-methylmesoporphyrin]]
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[[Category: N-methylmesoporphyrin]]
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[[Category: porphyrin metallation]]
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[[Category: Porphyrin metallation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:29:30 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:17:14 2008''
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Revision as of 09:29, 2 May 2008

Image:1c9e.gif

Template:STRUCTURE 1c9e

STRUCTURE OF FERROCHELATASE WITH COPPER(II) N-METHYLMESOPORPHYRIN COMPLEX BOUND AT THE ACTIVE SITE


Overview

Ferrochelatase, the enzyme catalyzing metallation of protoporphyrin IX at the terminal step of heme biosynthesis, was co-crystallized with an isomer mixture of the potent inhibitor N-methylmesoporphyrin (N-MeMP). The X-ray structure revealed the active site of the enzyme, to which only one of the isomers was bound, and for the first time allowed characterization of the mode of porphyrin macrocycle distortion by ferrochelatase. Crystallization of ferrochelatase and N-MeMP in the presence of Cu(2+) leads to metallation and demethylation of N-MeMP. A mechanism of porphyrin distortion is proposed, which assumes that the enzyme holds pyrrole rings B, C and D in a vice-like grip and forces a 36 degrees tilt on ring A.

About this Structure

1C9E is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

Structural and mechanistic basis of porphyrin metallation by ferrochelatase., Lecerof D, Fodje M, Hansson A, Hansson M, Al-Karadaghi S, J Mol Biol. 2000 Mar 17;297(1):221-32. PMID:10704318 Page seeded by OCA on Fri May 2 12:29:30 2008

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