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1cbf
From Proteopedia
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[[Image:1cbf.gif|left|200px]] | [[Image:1cbf.gif|left|200px]] | ||
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'''THE X-RAY STRUCTURE OF A COBALAMIN BIOSYNTHETIC ENZYME, COBALT PRECORRIN-4 METHYLTRANSFERASE, CBIF''' | '''THE X-RAY STRUCTURE OF A COBALAMIN BIOSYNTHETIC ENZYME, COBALT PRECORRIN-4 METHYLTRANSFERASE, CBIF''' | ||
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The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase., Schubert HL, Wilson KS, Raux E, Woodcock SC, Warren MJ, Nat Struct Biol. 1998 Jul;5(7):585-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9665173 9665173] | The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase., Schubert HL, Wilson KS, Raux E, Woodcock SC, Warren MJ, Nat Struct Biol. 1998 Jul;5(7):585-92. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9665173 9665173] | ||
[[Category: Bacillus megaterium]] | [[Category: Bacillus megaterium]] | ||
| - | [[Category: Precorrin-4 C(11)-methyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Raux, E.]] | [[Category: Raux, E.]] | ||
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[[Category: Wilson, K S.]] | [[Category: Wilson, K S.]] | ||
[[Category: Woodcock, S C.]] | [[Category: Woodcock, S C.]] | ||
| - | [[Category: | + | [[Category: Cobalamin biosynthesis]] |
| - | [[Category: | + | [[Category: Methylase]] |
| - | [[Category: | + | [[Category: Precorrin-4 methyltransferase]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:32:50 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:32, 2 May 2008
THE X-RAY STRUCTURE OF A COBALAMIN BIOSYNTHETIC ENZYME, COBALT PRECORRIN-4 METHYLTRANSFERASE, CBIF
Overview
Biosynthesis of the corrin ring of vitamin B12 requires the action of six S-adenosyl-L-methionine (AdoMet) dependent transmethylases, closely related in sequence. The first X-ray structure of one of these, cobalt-precorrin-4 transmethylase, CbiF, from Bacillus megaterium has been determined to a resolution of 2.4 A. CbiF contains two alphabeta domains forming a trough in which S-adenosyl-L-homocysteine (AdoHcy) binds. The location of AdoHcy and a number of conserved residues, helps define the precorrin binding site. A second crystal form determined at 3.1 A resolution highlights the flexibility of two loops around this site. CbiF employs a unique mode of AdoHcy binding and represents a new class of transmethylase.
About this Structure
1CBF is a Single protein structure of sequence from Bacillus megaterium. Full crystallographic information is available from OCA.
Reference
The X-ray structure of a cobalamin biosynthetic enzyme, cobalt-precorrin-4 methyltransferase., Schubert HL, Wilson KS, Raux E, Woodcock SC, Warren MJ, Nat Struct Biol. 1998 Jul;5(7):585-92. PMID:9665173 Page seeded by OCA on Fri May 2 12:32:50 2008
