Glucose 6-phosphate dehydrogenase

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== Function ==
== Function ==
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'''Glucose 6-phosphate dehydrogenase''' (G6PD) catalyzes the conversion of glucose 6-phosphate to 6-phospho-glucono-1,5-lactone. G6PD uses NAPD as cofactor<ref>PMID:9553122</ref>. See also [[G6PD (Hebrew)]].
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'''Glucose 6-phosphate dehydrogenase''' (G6PD) catalyzes the conversion of glucose 6-phosphate (G6P)to 6-phospho-glucono-1,5-lactone. G6PD uses NAPD as cofactor<ref>PMID:9553122</ref>. See also [[G6PD (Hebrew)]].
== Disease ==
== Disease ==
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**[[3c8n]] – MtG6PD (mutant) – ''Mycobacterium tuberculosis''<br />
**[[3c8n]] – MtG6PD (mutant) – ''Mycobacterium tuberculosis''<br />
**[[4e9i]] – TcG6PD – ''Trypanosoma cruzi''<br />
**[[4e9i]] – TcG6PD – ''Trypanosoma cruzi''<br />
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**[[3c8n]] – G6PD – ''Mycobacterium avium''<br />
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**[[4lgv]] – G6PD – ''Mycobacterium avium''<br />
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**[[5lxe]] – G6PD – ''Rhodococcus jostii''<br />
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*Glucose 6-phosphate dehydrogenase
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*Glucose 6-phosphate dehydrogenase complex
**[[2dpg]], [[1h9a]] – LmG6PD (mutant) + NADP<br />
**[[2dpg]], [[1h9a]] – LmG6PD (mutant) + NADP<br />
**[[1h94]] – LmG6PD (mutant) + NAD<br />
**[[1h94]] – LmG6PD (mutant) + NAD<br />
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**[[1e77]] – LmG6PD (mutant) + glucose 6-phosphate<br />
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**[[1e77]] – LmG6PD (mutant) + G6P<br />
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**[[1e7y]] – LmG6PD (mutant) + glucose 6-phosphate + NADP<br />
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**[[1e7y]] – LmG6PD (mutant) + G6P + NADP<br />
**[[1qki]], [[2bh9]] – hG6PD + NADP - human<br />
**[[1qki]], [[2bh9]] – hG6PD + NADP - human<br />
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**[[2bhl]] – hG6PD (mutant) + glucose 6-phosphate<br />
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**[[2bhl]], [[5ukw]] – hG6PD (mutant) + G6P<br />
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**[[4em5]] – TcG6PD + glucose 6-phosphate<br />
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**[[4em5]] – TcG6PD + G6P<br />
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**[[5aq1]] – TcG6PD + G6P + NADP<br />
**[[3b4y]] – MtG6PD (mutant) + coenzyme F420 <br />
**[[3b4y]] – MtG6PD (mutant) + coenzyme F420 <br />
}}
}}

Revision as of 09:41, 25 May 2017

Structure of glucose 6-phosphate dehydrogenase complex with glucose 6-phosphate and Ca+2 ion (green) (PDB code 1e77).

Drag the structure with the mouse to rotate

3D structures of glucose 6-phosphate dehydrogenase

Updated on 25-May-2017

References

  1. ↑ Tian WN, Braunstein LD, Pang J, Stuhlmeier KM, Xi QC, Tian X, Stanton RC. Importance of glucose-6-phosphate dehydrogenase activity for cell growth. J Biol Chem. 1998 Apr 24;273(17):10609-17. PMID:9553122
  2. ↑ Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. Lancet. 2008 Jan 5;371(9606):64-74. doi: 10.1016/S0140-6736(08)60073-2. PMID:18177777 doi:http://dx.doi.org/10.1016/S0140-6736(08)60073-2
  3. ↑ Cosgrove MS, Gover S, Naylor CE, Vandeputte-Rutten L, Adams MJ, Levy HR. An examination of the role of asp-177 in the His-Asp catalytic dyad of Leuconostoc mesenteroides glucose 6-phosphate dehydrogenase: X-ray structure and pH dependence of kinetic parameters of the D177N mutant enzyme. Biochemistry. 2000 Dec 12;39(49):15002-11. PMID:11106478

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