1cec

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[[Image:1cec.gif|left|200px]]
[[Image:1cec.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1cec |SIZE=350|CAPTION= <scene name='initialview01'>1cec</scene>, resolution 2.15&Aring;
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The line below this paragraph, containing "STRUCTURE_1cec", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Cellulase Cellulase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.4 3.2.1.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= MC1061 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1515 Clostridium thermocellum])
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|DOMAIN=
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{{STRUCTURE_1cec| PDB=1cec | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cec FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cec OCA], [http://www.ebi.ac.uk/pdbsum/1cec PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cec RCSB]</span>
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}}
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'''A COMMON PROTEIN FOLD AND SIMILAR ACTIVE SITE IN TWO DISTINCT FAMILIES OF BETA-GLYCANASES'''
'''A COMMON PROTEIN FOLD AND SIMILAR ACTIVE SITE IN TWO DISTINCT FAMILIES OF BETA-GLYCANASES'''
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[[Category: Alzari, P M.]]
[[Category: Alzari, P M.]]
[[Category: Dominguez, R.]]
[[Category: Dominguez, R.]]
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[[Category: cellulase]]
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[[Category: Cellulase]]
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[[Category: clostridium thermocellum]]
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[[Category: Clostridium thermocellum]]
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[[Category: endoglucanase c]]
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[[Category: Endoglucanase c]]
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[[Category: family a/5 of cellulases/glycosyl hydrolase]]
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[[Category: Family a/5 of cellulases/glycosyl hydrolase]]
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[[Category: glycosyl hydrolase]]
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[[Category: Glycosyl hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:38:14 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:19:59 2008''
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Revision as of 09:38, 2 May 2008

Image:1cec.gif

Template:STRUCTURE 1cec

A COMMON PROTEIN FOLD AND SIMILAR ACTIVE SITE IN TWO DISTINCT FAMILIES OF BETA-GLYCANASES


Overview

The structure of Clostridium thermocellum endoglucanase CelC, a member of the largest cellulase family (family A), has been determined at 2.15 A resolution. The protein folds into an (alpha/beta)8 barrel, with a deep active-site cleft generated by the insertion of a helical subdomain. The structure of the catalytic core of xylanase XynZ, which belongs to xylanase family F, has been determined at 1.4 A resolution. In spite of significant differences in substrate specificity and structure (including the absence of the helical subdomain), the general polypeptide folding pattern, architecture of the active site and catalytic mechanism of XynZ and CelC are similar, suggesting a common evolutionary origin.

About this Structure

1CEC is a Single protein structure of sequence from Clostridium thermocellum. Full crystallographic information is available from OCA.

Reference

A common protein fold and similar active site in two distinct families of beta-glycanases., Dominguez R, Souchon H, Spinelli S, Dauter Z, Wilson KS, Chauvaux S, Beguin P, Alzari PM, Nat Struct Biol. 1995 Jul;2(7):569-76. PMID:7664125 Page seeded by OCA on Fri May 2 12:38:14 2008

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