1cfd
From Proteopedia
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'''CALCIUM-FREE CALMODULIN''' | '''CALCIUM-FREE CALMODULIN''' | ||
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[[Category: Ren, H.]] | [[Category: Ren, H.]] | ||
[[Category: Tjandra, N.]] | [[Category: Tjandra, N.]] | ||
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Revision as of 09:40, 2 May 2008
CALCIUM-FREE CALMODULIN
Overview
The three-dimensional structure of calmodulin in the absence of Ca2+ has been determined by three- and four-dimensional heteronuclear NMR experiments, including ROE, isotope-filtering combined with reverse labelling, and measurement of more than 700 three-bond J-couplings. In analogy with the Ca(2+)-ligated state of this protein, it consists of two small globular domains separated by a flexible linker, with no stable, direct contacts between the two domains. In the absence of Ca2+, the four helices in each of the two globular domains form a highly twisted bundle, capped by a short anti-parallel beta-sheet. This arrangement is qualitatively similar to that observed in the crystal structure of the Ca(2+)-free N-terminal domain of troponin C.
About this Structure
1CFD is a Single protein structure of sequence from Xenopus laevis. The following page contains interesting information on the relation of 1CFD with [Calmodulin]. Full crystallographic information is available from OCA.
Reference
Solution structure of calcium-free calmodulin., Kuboniwa H, Tjandra N, Grzesiek S, Ren H, Klee CB, Bax A, Nat Struct Biol. 1995 Sep;2(9):768-76. PMID:7552748 Page seeded by OCA on Fri May 2 12:40:29 2008
