This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1cit
From Proteopedia
| Line 1: | Line 1: | ||
[[Image:1cit.gif|left|200px]] | [[Image:1cit.gif|left|200px]] | ||
| - | + | <!-- | |
| - | + | The line below this paragraph, containing "STRUCTURE_1cit", creates the "Structure Box" on the page. | |
| - | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
| - | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
| - | | | + | or leave the SCENE parameter empty for the default display. |
| - | | | + | --> |
| - | + | {{STRUCTURE_1cit| PDB=1cit | SCENE= }} | |
| - | + | ||
| - | + | ||
| - | }} | + | |
'''DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B''' | '''DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B''' | ||
| Line 27: | Line 24: | ||
[[Category: Meinke, G.]] | [[Category: Meinke, G.]] | ||
[[Category: Sigler, P B.]] | [[Category: Sigler, P B.]] | ||
| - | [[Category: | + | [[Category: Early immediate response gene product]] |
| - | [[Category: | + | [[Category: Minor groove interaction]] |
| - | [[Category: | + | [[Category: Monomeric protein-dna complex]] |
| - | [[Category: | + | [[Category: Orphan nuclear receptor]] |
| - | [[Category: | + | [[Category: Protein/dna]] |
| - | [[Category: | + | [[Category: Transcription factor]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:46:36 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:46, 2 May 2008
DNA-BINDING MECHANISM OF THE MONOMERIC ORPHAN NUCLEAR RECEPTOR NGFI-B
Overview
The 2.7 A X-ray crystal structure of the DNA-binding domain (DBD) of the orphan nuclear receptor, nerve growth factor-induced-B (NGFI-B), complexed to its high-affinity DNA target, represents the first structure analysis of a nuclear receptor DBD bound as a monomer to DNA. The structure of the core DBD and its interactions with the major groove of the DNA are similar to previously crystallographically solved DBD-DNA complexes in this superfamily; however, residues C-terminal to this core form a separate and unique substructure that interacts extensively and in a sequence-specific way with the minor groove of its DNA target, in particular with the characteristic 3 A-T base-pair identity element that extends 5' to the usual nuclear receptor half-site (AGGTCA).
About this Structure
1CIT is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
DNA-binding mechanism of the monomeric orphan nuclear receptor NGFI-B., Meinke G, Sigler PB, Nat Struct Biol. 1999 May;6(5):471-7. PMID:10331876 Page seeded by OCA on Fri May 2 12:46:36 2008
