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1cmi
From Proteopedia
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[[Image:1cmi.gif|left|200px]] | [[Image:1cmi.gif|left|200px]] | ||
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'''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE''' | '''STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1CMI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry | + | 1CMI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1b1w 1b1w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CMI OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Liang, J.]] | [[Category: Liang, J.]] | ||
[[Category: Snyder, S.]] | [[Category: Snyder, S.]] | ||
| - | [[Category: | + | [[Category: Dynein light chain]] |
| - | [[Category: | + | [[Category: Lc8]] |
| - | [[Category: | + | [[Category: Nno]] |
| - | [[Category: | + | [[Category: Pin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:53:33 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:53, 2 May 2008
STRUCTURE OF THE HUMAN PIN/LC8 DIMER WITH A BOUND PEPTIDE
Overview
The structure of the protein known both as neuronal nitric oxide synthase inhibitory protein, PIN (protein inhibitor of nNOS), and also as the 8 kDa dynein light chain (LC8) has been solved by X-ray diffraction. Two PIN/LC8 monomers related by a two-fold axis form a rectangular dimer. Two pairs of alpha-helices cover opposite faces, and each pair of helices packs against a beta-sheet with five antiparallel beta-strands. Each five-stranded beta-sheet contains four strands from one monomer and a fifth strand from the other monomer. A 13-residue peptide from nNOS is bound to the dimer in a deep hydrophobic groove as a sixth antiparallel beta-strand. The structure provides key insights into dimerization of and peptide binding by the multifunctional PIN/LC8 protein.
About this Structure
1CMI is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1b1w. Full crystallographic information is available from OCA.
Reference
Structure of the PIN/LC8 dimer with a bound peptide., Liang J, Jaffrey SR, Guo W, Snyder SH, Clardy J, Nat Struct Biol. 1999 Aug;6(8):735-40. PMID:10426949 Page seeded by OCA on Fri May 2 12:53:33 2008
Categories: Homo sapiens | Single protein | Clardy, J. | Guo, W. | Jaffery, S. | Liang, J. | Snyder, S. | Dynein light chain | Lc8 | Nno | Pin
