1cos
From Proteopedia
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[[Image:1cos.jpg|left|200px]] | [[Image:1cos.jpg|left|200px]] | ||
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'''CRYSTAL STRUCTURE OF A SYNTHETIC TRIPLE-STRANDED ALPHA-HELICAL BUNDLE''' | '''CRYSTAL STRUCTURE OF A SYNTHETIC TRIPLE-STRANDED ALPHA-HELICAL BUNDLE''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | The following page contains interesting information on the relation of 1COS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COS OCA]. | |
==Reference== | ==Reference== | ||
Crystal structure of a synthetic triple-stranded alpha-helical bundle., Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D, Science. 1993 Feb 26;259(5099):1288-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8446897 8446897] | Crystal structure of a synthetic triple-stranded alpha-helical bundle., Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D, Science. 1993 Feb 26;259(5099):1288-93. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/8446897 8446897] | ||
[[Category: Designer Proteins]] | [[Category: Designer Proteins]] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Cascio, D.]] | [[Category: Cascio, D.]] | ||
[[Category: Choe, S.]] | [[Category: Choe, S.]] | ||
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[[Category: Lovejoy, B.]] | [[Category: Lovejoy, B.]] | ||
[[Category: Mcrorie, D K.]] | [[Category: Mcrorie, D K.]] | ||
| - | [[Category: | + | [[Category: Alpha-helical bundle]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 12:57:20 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 09:57, 2 May 2008
CRYSTAL STRUCTURE OF A SYNTHETIC TRIPLE-STRANDED ALPHA-HELICAL BUNDLE
Overview
The x-ray crystal structure of a peptide designed to form a double-stranded parallel coiled coil shows that it is actually a triple-stranded coiled coil formed by three alpha-helices. Unlike the designed parallel coiled coil, the helices run up-up-down. The structure is stabilized by a distinctive hydrophobic interface consisting of eight layers. As in the design, each alpha-helix in the coiled coil contributes one leucine side chain to each layer. The structure suggests that hydrophobic interactions are a dominant factor in the stabilization of coiled coils. The stoichiometry and geometry of coiled coils are primarily determined by side chain packing in the solvent-inaccessible interior, but electrostatic interactions also contribute.
About this Structure
The following page contains interesting information on the relation of 1COS with [Designer Proteins]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a synthetic triple-stranded alpha-helical bundle., Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D, Science. 1993 Feb 26;259(5099):1288-93. PMID:8446897 Page seeded by OCA on Fri May 2 12:57:20 2008
