1dnv

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(Difference between revisions)

Revision as of 07:47, 13 December 2017

PARVOVIRUS (DENSOVIRUS) FROM GALLERIA MELLONELLA

Structural highlights

1dnv is a 1 chain structure with sequence from Galleria mellonella densovirus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[CAPSD_GMDNV] Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of size variants of the capsid proteins, which differ in the N-terminushe capsid encapsulates the genomic ssDNA. Capsid proteins are responsible for the attachment to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis (By similarity).

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

BACKGROUND: Parvoviruses infect vertebrates, insects and crustaceans. Many arthropod parvoviruses (densoviruses) are highly pathogenic and kill approximately 90% of the host larvae within days, making them potentially effective as selective pesticides. Improved understanding of densoviral structure and function is therefore desirable. There are four different initiation sites for translation of the densovirus capsid protein mRNA, giving rise to the viral proteins VP1 to VP4. Sixty copies of the common, C-terminal domain make up the ordered part of the icosahedral capsid. RESULTS: The Galleria mellonella densovirus (GMDNV) capsid protein consists of a core beta-barrel motif, similar to that found in many other viral capsid proteins. The structure most closely resembles that of the vertebrate parvoviruses, but it has diverged beyond recognition in many of the long loop regions that constitute the surface features and intersubunit contacts. The N termini of twofold-related subunits have swapped their positions relative to those of the vertebrate parvoviruses. Unlike in the vertebrate parvoviruses, in GmDNV there is no continuous electron density in the channels running along the fivefold axes of the virus. Electron density corresponding to some of the single-stranded DNA genome is visible in the crystal structure, but it is not as well defined as in the vertebrate parvoviruses. CONCLUSIONS: The sequence of the glycine-rich motif, which occupies each of the channels along the fivefold axes in vertebrate viruses, is conserved between mammalian and insect parvoviruses. This motif may serve to externalize the N-terminal region of the single VP1 subunit per particle. The domain swapping of the N termini between insect and vertebrate parvoviruses may have the effect of increasing capsid stability in GmDNV.

The structure of an insect parvovirus (Galleria mellonella densovirus) at 3.7 A resolution.,Simpson AA, Chipman PR, Baker TS, Tijssen P, Rossmann MG Structure. 1998 Nov 15;6(11):1355-67. PMID:9817847^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Simpson AA, Chipman PR, Baker TS, Tijssen P, Rossmann MG. The structure of an insect parvovirus (Galleria mellonella densovirus) at 3.7 A resolution. Structure. 1998 Nov 15;6(11):1355-67. PMID:9817847

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1dnv"

@@ Line 1: / Line 1: @@
 ==PARVOVIRUS (DENSOVIRUS) FROM GALLERIA MELLONELLA==
 <StructureSection load='1dnv' size='340' side='right' caption='[[1dnv]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1dnv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Gmdnv Gmdnv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DNV FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1dnv]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Galleria_mellonella_densovirus Galleria mellonella densovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DNV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1DNV FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dnv OCA], [http://pdbe.org/1dnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dnv RCSB], [http://www.ebi.ac.uk/pdbsum/1dnv PDBsum]</span></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1dnv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dnv OCA], [http://pdbe.org/1dnv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1dnv RCSB], [http://www.ebi.ac.uk/pdbsum/1dnv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1dnv ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 11: / Line 12: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/1dnv_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dn/1dnv_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 26: / Line 27: @@
 </div>
 <div class="pdbe-citations 1dnv" style="background-color:#fffaf0;"></div>
-==See Also==
-*[[Virus coat protein|Virus coat protein]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Gmdnv]]
+[[Category: Galleria mellonella densovirus]]
 [[Category: Baker, T S]]
 [[Category: Chipmann, P R]]

1dnv

From Proteopedia

Revision as of 07:47, 13 December 2017

PARVOVIRUS (DENSOVIRUS) FROM GALLERIA MELLONELLA

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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