1csk

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[[Image:1csk.gif|left|200px]]
[[Image:1csk.gif|left|200px]]
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{{Structure
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|PDB= 1csk |SIZE=350|CAPTION= <scene name='initialview01'>1csk</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1csk", creates the "Structure Box" on the page.
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1csk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csk OCA], [http://www.ebi.ac.uk/pdbsum/1csk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1csk RCSB]</span>
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'''THE CRYSTAL STRUCTURE OF HUMAN CSKSH3: STRUCTURAL DIVERSITY NEAR THE RT-SRC AND N-SRC LOOP'''
'''THE CRYSTAL STRUCTURE OF HUMAN CSKSH3: STRUCTURAL DIVERSITY NEAR THE RT-SRC AND N-SRC LOOP'''
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[[Category: Mathieu, M.]]
[[Category: Mathieu, M.]]
[[Category: Wierenga, R K.]]
[[Category: Wierenga, R K.]]
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[[Category: phosphotransferase]]
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[[Category: Phosphotransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:04:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:27:43 2008''
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Revision as of 10:04, 2 May 2008

Image:1csk.gif

Template:STRUCTURE 1csk

THE CRYSTAL STRUCTURE OF HUMAN CSKSH3: STRUCTURAL DIVERSITY NEAR THE RT-SRC AND N-SRC LOOP


Overview

SH3 domains are modules occurring in diverse proteins, ranging from cytoskeletal proteins to signaling proteins, such as tyrosine kinases. The crystal structure of the SH3 domain of Csk (c-Src specific tyrosine kinase) has been refined at a resolution of 2.5 A, with an R-factor of 22.4%. The structure is very similar to the FynSH3 crystal structure. When comparing CskSH3 and FynSH3 it is seen that the structural and charge differences of the RT-Src loop and the n-Src loop, near the conserved Trp47, correlate with different binding properties of these SH3 domains. The structure comparison suggests that those glycines and acid residues which are very well conserved in the SH3 sequences are important for the stability of the SH3 fold.

About this Structure

1CSK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The crystal structure of human CskSH3: structural diversity near the RT-Src and n-Src loop., Borchert TV, Mathieu M, Zeelen JP, Courtneidge SA, Wierenga RK, FEBS Lett. 1994 Mar 14;341(1):79-85. PMID:7511113 Page seeded by OCA on Fri May 2 13:04:17 2008

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