1csl

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[[Image:1csl.jpg|left|200px]]
[[Image:1csl.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1csl |SIZE=350|CAPTION= <scene name='initialview01'>1csl</scene>, resolution 1.60&Aring;
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The line below this paragraph, containing "STRUCTURE_1csl", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_1csl| PDB=1csl | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1csl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1csl OCA], [http://www.ebi.ac.uk/pdbsum/1csl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1csl RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE'''
'''CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE'''
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==About this Structure==
==About this Structure==
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1CSL is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CSL OCA].
==Reference==
==Reference==
The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution., Ippolito JA, Steitz TA, J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10656783 10656783]
The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution., Ippolito JA, Steitz TA, J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10656783 10656783]
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[[Category: Protein complex]]
 
[[Category: Ippolito, J A.]]
[[Category: Ippolito, J A.]]
[[Category: Steitz, T A.]]
[[Category: Steitz, T A.]]
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[[Category: hiv-1]]
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[[Category: Hiv-1]]
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[[Category: rre high affinity site]]
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[[Category: Rre high affinity site]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:04:18 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:27:46 2008''
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Revision as of 10:04, 2 May 2008

Image:1csl.jpg

Template:STRUCTURE 1csl

CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE


Overview

The crystal structure of a 28 nt RNA fragment containing the human immunodeficiency virus type 1 (HIV-1) Rev response element high affinity binding site for Rev protein has been solved at 1.6 A resolution. The overall structure of the RRE helix is greatly distorted from A-form geometry by the presence of two purine-purine base-pairs and two single nucleotide bulges. G48 and G71 form a Hoogsteen-type asymmetric base-pair with G71 adopting a syn conformation. The non-canonical regions in the unliganded Rev response element molecule narrow the major groove width with respect to standard A-RNA. The Rev response element structure observed here represents a closed form of the Rev binding site and differs from conformations of the RNA observed previously by solution NMR studies.

About this Structure

Full crystallographic information is available from OCA.

Reference

The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution., Ippolito JA, Steitz TA, J Mol Biol. 2000 Jan 28;295(4):711-7. PMID:10656783 Page seeded by OCA on Fri May 2 13:04:18 2008

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