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3bew

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Revision as of 07:32, 31 October 2018

10mer Crystal Structure of chicken MHC class I haplotype B21

Structural highlights

3bew is a 6 chain structure with sequence from Chick. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:	3bev, 1ogt, 1oga, 1sys, 1a1m, 1im9, 1qqd, 1kpr, 1ktl, 1mhe, 2esv, 1ydp, 2dyp, 2d31, 1kjv
Gene:	BFIV21, B-FIV, BF2 (CHICK), B2M (CHICK)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[TBB6_CHICK] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. [B2MG_CHICK] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Little is known about the structure of major histocompatibility complex (MHC) molecules outside of mammals. Only one class I molecule in the chicken MHC is highly expressed, leading to strong genetic associations with infectious pathogens. Here, we report two structures of the MHC class I molecule BF2*2101 from the B21 haplotype, which is known to confer resistance to Marek's disease caused by an oncogenic herpesvirus. The binding groove has an unusually large central cavity, which confers substantial conformational flexibility to the crucial residue Arg9, allowing remodeling of key peptide-binding sites. The coupled variation of anchor residues from the peptide, utilizing a charge-transfer system unprecedented in MHC molecules, allows peptides with conspicuously different sequences to be bound. This promiscuous binding extends our understanding of ways in which MHC class I molecules can present peptides to the immune system and might explain the resistance of the B21 haplotype to Marek's disease.

Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding.,Koch M, Camp S, Collen T, Avila D, Salomonsen J, Wallny HJ, van Hateren A, Hunt L, Jacob JP, Johnston F, Marston DA, Shaw I, Dunbar PR, Cerundolo V, Jones EY, Kaufman J Immunity. 2007 Dec;27(6):885-99. PMID:18083574^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Koch M, Camp S, Collen T, Avila D, Salomonsen J, Wallny HJ, van Hateren A, Hunt L, Jacob JP, Johnston F, Marston DA, Shaw I, Dunbar PR, Cerundolo V, Jones EY, Kaufman J. Structures of an MHC class I molecule from B21 chickens illustrate promiscuous peptide binding. Immunity. 2007 Dec;27(6):885-99. PMID:18083574 doi:10.1016/j.immuni.2007.11.007

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 See Also
6 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3bew"

@@ Line 1: / Line 1: @@
 ==10mer Crystal Structure of chicken MHC class I haplotype B21==
 <StructureSection load='3bew' size='340' side='right' caption='[[3bew]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
@@ Line 5: / Line 6: @@
 </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3bev|3bev]], [[1ogt|1ogt]], [[1oga|1oga]], [[1sys|1sys]], [[1a1m|1a1m]], [[1im9|1im9]], [[1qqd|1qqd]], [[1kpr|1kpr]], [[1ktl|1ktl]], [[1mhe|1mhe]], [[2esv|2esv]], [[1ydp|1ydp]], [[2dyp|2dyp]], [[2d31|2d31]], [[1kjv|1kjv]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BFIV21, B-FIV, BF2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK]), B2M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9031 CHICK])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bew OCA], [http://pdbe.org/3bew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bew RCSB], [http://www.ebi.ac.uk/pdbsum/3bew PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3bew FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3bew OCA], [http://pdbe.org/3bew PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3bew RCSB], [http://www.ebi.ac.uk/pdbsum/3bew PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3bew ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 13: / Line 14: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3bew_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/be/3bew_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 63: / Line 64: @@
 [[Category: Microtubule]]
 [[Category: Nucleotide-binding]]
+[[Category: Polymorphism]]
 [[Category: Secreted]]
 [[Category: Water cushion]]

3bew

From Proteopedia

Revision as of 07:32, 31 October 2018

10mer Crystal Structure of chicken MHC class I haplotype B21

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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