1cvj
From Proteopedia
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'''X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA''' | '''X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA''' | ||
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[[Category: Deo, R C.]] | [[Category: Deo, R C.]] | ||
[[Category: Sonenberg, N.]] | [[Category: Sonenberg, N.]] | ||
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| - | [[Category: | + | [[Category: Rrm]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:09:24 2008'' | |
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Revision as of 10:09, 2 May 2008
X-RAY CRYSTAL STRUCTURE OF THE POLY(A)-BINDING PROTEIN IN COMPLEX WITH POLYADENYLATE RNA
Overview
The cocrystal structure of human poly(A)-binding protein (PABP) has been determined at 2.6 A resolution. PABP recognizes the 3' mRNA poly(A) tail and plays critical roles in eukaryotic translation initiation and mRNA stabilization/degradation. The minimal PABP used in this study consists of the N-terminal two RRM-type RNA-binding domains connected by a short linker (RRM1/2). These two RRMs form a continuous RNA-binding trough, lined by an antiparallel beta sheet backed by four alpha helices. The polyadenylate RNA adopts an extended conformation running the length of the molecular trough. Adenine recognition is primarily mediated by contacts with conserved residues found in the RNP motifs of the two RRMs. The convex dorsum of RRM1/2 displays a phylogenetically conserved hydrophobic/acidic portion, which may interact with translation initiation factors and regulatory proteins.
About this Structure
1CVJ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Recognition of polyadenylate RNA by the poly(A)-binding protein., Deo RC, Bonanno JB, Sonenberg N, Burley SK, Cell. 1999 Sep 17;98(6):835-45. PMID:10499800 Page seeded by OCA on Fri May 2 13:09:24 2008
