1f31
From Proteopedia
(New page: 200px<br /> <applet load="1f31" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f31, resolution 2.6Å" /> '''CRYSTAL STRUCTURE OF...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1F31 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]] with ZN and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1F31 OCA]]. | + | 1F31 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Clostridium_botulinum Clostridium botulinum]] with ZN and SO4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Bontoxilysin Bontoxilysin]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.69 3.4.24.69]]. Structure known Active Site: ZN1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1F31 OCA]]. |
==Reference== | ==Reference== | ||
Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B., Swaminathan S, Eswaramoorthy S, Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10932256 10932256] | Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B., Swaminathan S, Eswaramoorthy S, Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=10932256 10932256] | ||
| + | [[Category: Bontoxilysin]] | ||
[[Category: Clostridium botulinum]] | [[Category: Clostridium botulinum]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: zinc]] | [[Category: zinc]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 11:02:14 2007'' |
Revision as of 08:57, 30 October 2007
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CRYSTAL STRUCTURE OF CLOSTRIDIUM BOTULINUM NEUROTOXIN B COMPLEXED WITH A TRISACCHARIDE
Overview
Clostridium botulinum neurotoxins are among the most potent toxins to, humans. The crystal structures of intact C. botulinum neurotoxin type B, (BoNT/B) and its complex with sialyllactose, determined at 1. 8 and 2.6 A, resolution, respectively, provide insight into its catalytic and binding, sites. The position of the belt region in BoNT/B is different from that in, BoNT/A; this observation presents interesting possibilities for designing, specific inhibitors that could be used to block the activity of this, neurotoxin. The structures of BoNT/B and its complex with sialyllactose, provide a detailed description of the active site and a model for, interactions between the toxin and its cell surface receptor. The latter, may provide valuable information for recombinant vaccine development.
About this Structure
1F31 is a [Single protein] structure of sequence from [Clostridium botulinum] with ZN and SO4 as [ligands]. Active as [Bontoxilysin], with EC number [3.4.24.69]. Structure known Active Site: ZN1. Full crystallographic information is available from [OCA].
Reference
Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B., Swaminathan S, Eswaramoorthy S, Nat Struct Biol. 2000 Aug;7(8):693-9. PMID:10932256
Page seeded by OCA on Tue Oct 30 11:02:14 2007
Categories: Bontoxilysin | Clostridium botulinum | Single protein | Eswaramoorthy, S. | Swaminathan, S. | SO4 | ZN | Botulinum | Complex | Ganglioside | Metalloprotease | Neurotoxin | Transmembrane | Zinc
