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1cxz

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[[Image:1cxz.gif|left|200px]]
[[Image:1cxz.gif|left|200px]]
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{{Structure
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|RELATEDENTRY=[[1a2b|1A2B]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1cxz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cxz OCA], [http://www.ebi.ac.uk/pdbsum/1cxz PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1cxz RCSB]</span>
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'''CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1'''
'''CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1'''
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[[Category: Maesaki, R.]]
[[Category: Maesaki, R.]]
[[Category: Shimizu, T.]]
[[Category: Shimizu, T.]]
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[[Category: antiparallel coiled-coil]]
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[[Category: Antiparallel coiled-coil]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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Revision as of 10:13, 2 May 2008

Image:1cxz.gif

Template:STRUCTURE 1cxz

CRYSTAL STRUCTURE OF HUMAN RHOA COMPLEXED WITH THE EFFECTOR DOMAIN OF THE PROTEIN KINASE PKN/PRK1


Overview

The small G protein Rho has emerged as a key regulator of cellular events involving cytoskeletal reorganization. Here we report the 2.2 A crystal structure of RhoA bound to an effector domain of protein kinase PKN/PRK1. The structure reveals the antiparallel coiled-coil finger (ACC finger) fold of the effector domain that binds to the Rho specificity-determining regions containing switch I, beta strands B2 and B3, and the C-terminal alpha helix A5, predominantly by specific hydrogen bonds. The ACC finger fold is distinct from those for other small G proteins and provides evidence for the diverse ways of effector recognition. Sequence analysis based on the structure suggests that the ACC finger fold is widespread in Rho effector proteins.

About this Structure

1CXZ is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1., Maesaki R, Ihara K, Shimizu T, Kuroda S, Kaibuchi K, Hakoshima T, Mol Cell. 1999 Nov;4(5):793-803. PMID:10619026 Page seeded by OCA on Fri May 2 13:13:54 2008

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