3e3a

From Proteopedia

(Difference between revisions)

Revision as of 09:01, 25 October 2017

The Structure of Rv0554 from Mycobacterium tuberculosis

Structural highlights

3e3a is a 2 chain structure with sequence from "bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	3hss
Gene:	bpoC, MT0580, Rv0554 ("Bacillus tuberculosis" (Zopf 1883) Klein 1884)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

Mycobacterium tuberculosis, the cause of tuberculosis, is a devastating human pathogen against which new drugs are urgently needed. Enzymes from the biosynthetic pathway for menaquinone are considered to be valid drug targets. The protein encoded by the open reading frame Rv0554 has been expressed, purified and subjected to structural and functional analysis to test for a putative role in menaquinone biosynthesis. The crystal structure of Rv0554 has been solved and refined in two different space groups at 2.35 and 1.9 A resolution. The protein is dimeric, with an alpha/beta-hydrolase monomer fold. In each monomer, a large cavity adjacent to the catalytic triad is enclosed by a helical lid. Dimerization is mediated by the lid regions. Small-molecule additives used in crystallization bind in the active site, but no binding of ligands related to menaquinone biosynthesis could be detected and functional assays failed to support possible roles in menaquinone biosynthesis.

Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis.,Johnston JM, Jiang M, Guo Z, Baker EN Acta Crystallogr D Biol Crystallogr. 2010 Aug;66(Pt 8):909-17. Epub 2010, Jul 10. PMID:20693690^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Johnston JM, Jiang M, Guo Z, Baker EN. Structural and functional analysis of Rv0554 from Mycobacterium tuberculosis: testing a putative role in menaquinone biosynthesis. Acta Crystallogr D Biol Crystallogr. 2010 Aug;66(Pt 8):909-17. Epub 2010, Jul 10. PMID:20693690 doi:10.1107/S0907444910025771

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3e3a"

Categories: Baker, E N | Johnston, J M | Alpha/beta hydrolase | Oxidoreductase | Peroxidase

@@ Line 1: / Line 1: @@
 ==The Structure of Rv0554 from Mycobacterium tuberculosis==
 <StructureSection load='3e3a' size='340' side='right' caption='[[3e3a]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3hss|3hss]]</td></tr>
 <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">bpoC, MT0580, Rv0554 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e3a OCA], [http://pdbe.org/3e3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e3a RCSB], [http://www.ebi.ac.uk/pdbsum/3e3a PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3e3a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3e3a OCA], [http://pdbe.org/3e3a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3e3a RCSB], [http://www.ebi.ac.uk/pdbsum/3e3a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3e3a ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==

3e3a

From Proteopedia

Revision as of 09:01, 25 October 2017

The Structure of Rv0554 from Mycobacterium tuberculosis

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox