1d0q

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[[Image:1d0q.gif|left|200px]]
[[Image:1d0q.gif|left|200px]]
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{{Structure
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|PDB= 1d0q |SIZE=350|CAPTION= <scene name='initialview01'>1d0q</scene>, resolution 1.71&Aring;
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The line below this paragraph, containing "STRUCTURE_1d0q", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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{{STRUCTURE_1d0q| PDB=1d0q | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1d0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1d0q OCA], [http://www.ebi.ac.uk/pdbsum/1d0q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1d0q RCSB]</span>
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'''STRUCTURE OF THE ZINC-BINDING DOMAIN OF BACILLUS STEAROTHERMOPHILUS DNA PRIMASE'''
'''STRUCTURE OF THE ZINC-BINDING DOMAIN OF BACILLUS STEAROTHERMOPHILUS DNA PRIMASE'''
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[[Category: Pan, H.]]
[[Category: Pan, H.]]
[[Category: Wigley, D B.]]
[[Category: Wigley, D B.]]
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[[Category: dna primase]]
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[[Category: Dna primase]]
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[[Category: protein]]
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[[Category: Protein]]
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[[Category: zinc-binding motif]]
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[[Category: Zinc-binding motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 13:19:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:32:10 2008''
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Revision as of 10:19, 2 May 2008

Image:1d0q.gif

Template:STRUCTURE 1d0q

STRUCTURE OF THE ZINC-BINDING DOMAIN OF BACILLUS STEAROTHERMOPHILUS DNA PRIMASE


Overview

BACKGROUND: DNA primases catalyse the synthesis of the short RNA primers that are required for DNA replication by DNA polymerases. Primases comprise three functional domains: a zinc-binding domain that is responsible for template recognition, a polymerase domain, and a domain that interacts with the replicative helicase, DnaB. RESULTS: We present the crystal structure of the zinc-binding domain of DNA primase from Bacillus stearothermophilus, determined at 1.7 A resolution. This is the first high-resolution structural information about any DNA primase. A model is discussed for the interaction of this domain with the single-stranded DNA template. CONCLUSIONS: The structure of the DNA primase zinc-binding domain confirms that the protein belongs to the zinc ribbon subfamily. Structural comparison with other nucleic acid binding proteins suggests that the beta sheet of primase is likely to be the DNA-binding surface, with conserved residues on this surface being involved in the binding and recognition of DNA.

About this Structure

1D0Q is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Structure of the zinc-binding domain of Bacillus stearothermophilus DNA primase., Pan H, Wigley DB, Structure. 2000 Mar 15;8(3):231-9. PMID:10745010 Page seeded by OCA on Fri May 2 13:19:08 2008

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