2vy9

From Proteopedia

(Difference between revisions)

Revision as of 20:44, 19 September 2018

Molecular architecture of the stressosome, a signal integration and transduction hub

Structural highlights

2vy9 is a 2 chain structure with sequence from Atcc 35608. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
NonStd Res:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

A commonly used strategy by microorganisms to survive multiple stresses involves a signal transduction cascade that increases the expression of stress-responsive genes. Stress signals can be integrated by a multiprotein signaling hub that responds to various signals to effect a single outcome. We obtained a medium-resolution cryo-electron microscopy reconstruction of the 1.8-megadalton "stressosome" from Bacillus subtilis. Fitting known crystal structures of components into this reconstruction gave a pseudoatomic structure, which had a virus capsid-like core with sensory extensions. We suggest that the different sensory extensions respond to different signals, whereas the conserved domains in the core integrate the varied signals. The architecture of the stressosome provides the potential for cooperativity, suggesting that the response could be tuned dependent on the magnitude of chemophysical insult.

Molecular architecture of the "stressosome," a signal integration and transduction hub.,Marles-Wright J, Grant T, Delumeau O, van Duinen G, Firbank SJ, Lewis PJ, Murray JW, Newman JA, Quin MB, Race PR, Rohou A, Tichelaar W, van Heel M, Lewis RJ Science. 2008 Oct 3;322(5898):92-6. PMID:18832644^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Marles-Wright J, Grant T, Delumeau O, van Duinen G, Firbank SJ, Lewis PJ, Murray JW, Newman JA, Quin MB, Race PR, Rohou A, Tichelaar W, van Heel M, Lewis RJ. Molecular architecture of the "stressosome," a signal integration and transduction hub. Science. 2008 Oct 3;322(5898):92-6. PMID:18832644 doi:322/5898/92

1 Structural highlights
2 Evolutionary Conservation
3 Publication Abstract from PubMed
4 See Also
5 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2vy9"

@@ Line 1: / Line 1: @@
-==MOLECULAR ARCHITECTURE OF THE STRESSOSOME, A SIGNAL INTEGRATION AND TRANSDUCTION HUB==
+==Molecular architecture of the stressosome, a signal integration and transduction hub==
 <StructureSection load='2vy9' size='340' side='right' caption='[[2vy9]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
 == Structural highlights ==
 <table><tr><td colspan='2'>[[2vy9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Atcc_35608 Atcc 35608]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VY9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2VY9 FirstGlance]. <br>
 </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vy9 OCA], [http://pdbe.org/2vy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vy9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vy9 PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2vy9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vy9 OCA], [http://pdbe.org/2vy9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2vy9 RCSB], [http://www.ebi.ac.uk/pdbsum/2vy9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2vy9 ProSAT]</span></td></tr>
 </table>
 == Evolutionary Conservation ==
@@ Line 10: / Line 11: @@
 Check<jmol>
   <jmolCheckbox>
-    <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/2vy9_consurf.spt"</scriptWhenChecked>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vy/2vy9_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 25: / Line 26: @@
 </div>
 <div class="pdbe-citations 2vy9" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Anti-sigma factor antagonist|Anti-sigma factor antagonist]]
 == References ==
 <references/>
@@ Line 31: / Line 35: @@
 [[Category: Atcc 35608]]
 [[Category: Delumeau, O]]
-[[Category: Duinen, G Van]]
+[[Category: Duinen, G van]]
 [[Category: Firbank, S J]]
 [[Category: Grant, T]]
-[[Category: Heel, M Van]]
+[[Category: Heel, M van]]
 [[Category: Lewis, P J]]
 [[Category: Lewis, R J]]

2vy9

From Proteopedia

Revision as of 20:44, 19 September 2018

Molecular architecture of the stressosome, a signal integration and transduction hub

Structural highlights

Evolutionary Conservation

Publication Abstract from PubMed

See Also

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

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